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Functional cooperation occurs between unique subclones within an individual tumour in a mouse mammary tumour virus (MMTV)–WNT1 mouse model of breast cancer.
This paper reports that the spliced form of X-box-binding protein 1, which is activated as part of the unfolded protein response, regulates a hypoxia-inducible factor 1α-dependent transcriptional network in triple-negative breast cancer cells.
Two papers find that targeting MTH1, an enzyme that prevents the incorporation of oxidized purine nucleotides into DNA, causes lethality in various tumour cell lines.
Shahin Rafii, Bi-Sen Ding and colleagues show that crosstalk between endothelial cells and lymphoma cells promotes lymphomagenesis and resistance to chemotherapy.
Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and protein expression, point to biological functions and molecular pathways being deregulated in multiple cancers. The integrative genomics methodologies that are used to interpret these data can seem daunting, but are discussed in this Review in simplistic terms and in the context of their use in cancer research.
The family of insulin-like growth factor (IGF) binding proteins (IGFBPs) have many actions beyond their endocrine role in IGF transport. IGFBPs regulate cell growth and survival, gene transcription, induction of apoptosis and DNA damage repair. These findings point to the intimate involvement of IGFBPs in tumour development, progression and resistance to treatment.
Although epidemiological and early clinical trials are inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for vitamin D, this Review assesses the evidence that vitamin D is important in cancer prevention.
There are many cellular outcomes attributable to p53 activation, but identifying which of these, or which combination of these, is important for tumour suppression has remained challenging. As new roles for p53 emerge, this Opinion dissects the role of p53 in tumour suppression.
This Opinion article discusses how principles that are applied to the study of ecology might be relevant to the study of cancer. Focusing on population dynamics, this article provides suggestions and ideas for understanding tumour growth and how this might provide strategies for eradication.
