Sorrentino and colleagues found that the transcriptional activity and nuclear localization of YAP and TAZ (mediators of the Hippo pathway) are regulated by the mevalonate pathway. Geranylgeranyl pyrophosphate is produced by the mevalonate pathway and this is required for activation of RHO GTPase, which in turn activates YAP and TAZ. Moreover, inhibition of the mevalonate pathway in Drosophila melanogaster suppresses the eye overgrowth phenotype that is characteristic of Hippo pathway activation.
References
Sorrentino, G. et al. Metabolic control of YAP and TAZ by the mevalonate pathway. Nature Cell Biol. 16, 357–366 (2014)
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Alderton, G. A mevalonate pathway–Hippo pathway connection. Nat Rev Cancer 14, 298 (2014). https://doi.org/10.1038/nrc3740
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DOI: https://doi.org/10.1038/nrc3740
