Abstract

The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-tumorigenic conditions provides insights into normal homeostatic cellular responses to low oxygen levels (hypoxia). Many tumours contain genetic alterations, such as MYC activation, that can collaborate with HIF to confer metabolic advantages to tumour cells, which tend to exist in a hypoxic microenvironment. This Perspective emphasizes the differences between the transcriptional network that operates under normal homeostatic conditions and the network in a tumorigenic milieu.

Author affiliations

1. Chi V. Dang and Ping Gao are at, and Jung-whan Kim was at, the Division of Hematology, Department of Medicine, Chi V. Dang is also at the Department of Cell Biology, the Department of Oncology and the Department of Pathology, and Jason Yustein is at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
2. Jung-whan Kim is now at the Department of Anatomy, University of California, San Francisco, Health Science West 1301, 513 Parnassus Avenue, San Francisco, California 94143, USA.

Correspondence to: Chi V. Dang¹ Email: cvdang@jhmi.edu

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