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Two papers demonstrate that early disseminated cancer cells (DCCs) from HER2+breast cancer are more likely to seed metastasis than those from established tumours.
Grabocka and Bar-Sagi have shown that cells expressing mutant KRAS upregulate SGs in response to stress, and that this enhances the survival of both KRAS-mutant and wild-type cells.
Davidsonet al. used an implantable microdevice to show that pancreatic tumours in vivocatabolize proteins in their local environment, by macropinocytosis, to derive amino acids for cell growth.
Salvador Aznar Benitah and colleagues have identified a subpopulation of cells with high metastatic potential that express high levels of the fatty acid receptor CD36 in human oral carcinoma samples.
In this Review, Dienstmannet al. analyse the complex nature of colorectal cancer and the different subtypes in which this disease can be classified, advocating for a 'multi-molecular' perspective for the development of therapies to treat it.
Proteins regulating cell cycle progression are involved in the formation of most cancer types. This Review discusses the role of cell cycle proteins in cancer, the rationale for targeting them in cancer treatment, results of clinical trials, as well as future therapeutic potential of various cell cycle inhibitors.
This Opinion article discusses the recurring regulatory architecture that is both necessary and sufficient to maintain tumour cell state. Considering this architecture provides a valuable reductionist framework to study the genetic heterogeneity of human disease and to drive key translational applications.
This Opinion article discusses the various migration modes used by cancer cells in confining microenvironments and explains how understanding confined cancer cell motilityin vivo through the application of engineered in vitromodels could help to develop therapeutic approaches to prevent metastases.
