Wang, Liu and colleagues examined the pathways associated with tyrosine kinase inhibitor (TKI) resistance of BCR–ABL T315I-mutant chronic myeloid leukaemia (CML) cells and found that the expression of genes associated with myeloid differentiation was reduced. Treating BCR–ABL-expressing CML cells with all-trans retinoic acid induced differentiation and prevented acquisition of the T315I mutation and TKI resistance.
References
Wang, Z. et al. ATRA-induced cellular differentiation and CD38 expression inhibits acquisition of BCR-ABL mutations for CML acquired resistance. PLoS Genet. http://dx.doi.org/10.1371/journal.pgen.1004414 (2014)
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Alderton, G. Inducing differentiation. Nat Rev Cancer 14, 515 (2014). https://doi.org/10.1038/nrc3797
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DOI: https://doi.org/10.1038/nrc3797
