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The public health importance of Barrett's oesophagus lies in its association with oesophageal adenocarcinoma, the incidence of which is rising steadily. However, 95% of oesophageal adenocarcinomas arise in individuals without a prior diagnosis of Barrett's oesophagus. What strategies can be used to reduce late diagnosis of oesophageal adenocarcinoma?
The inability to faithfully segregate chromosomes to two daughter cells during mitosis — leading to aneuploidy — is a widespread phenomenon in solid tumours that is thought to promote tumorigenic progression. This Review discusses how mitotic chromosomal instability might arise in tumours and what its consequences might be.
Fibroblast growth factors (FGFs) and their receptors have been shown to drive tumorigenesis and tumour progression. However, FGF signalling can also be tumour suppressive, and understanding the mechanisms that underlie these context-specific effects will be important to rationally target FGF signalling for therapeutic benefit.
It is becoming clear that targeting individual kinases is not sufficient to block the growth of most cancers. This Perspective discusses some of the strategies being used to identify new therapeutic combinations of kinase targets.
The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. This article proposes that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair through an angiocrine mechanism.
Multidrug transporter proteins contribute to chemoresistance through the efflux of anticancer drugs from cancer cells. However, evidence also points to their importance in cancer beyond drug efflux. Is there more to this family than meets the eye?
