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    Here we present a series of specially commissioned articles that discuss the key issues and our current knowledge of MYC and cancer. Since the isolation of the MYC oncogene in the early 1980's, the concepts that try to explain how this transcription factor contributes to tumorigenesis are numerous and encompass many fields. And yet, new ideas about MYC–dependent responses and how these might be involved in tumorigenesis are still emerging as the repertoire of signalling pathways that are induced downstream of MYC activation expand. In addition, key concepts implicit in the consideration of how MYC might function as an oncogene are also likely to be relevant to other oncogenes and transcription factors, and may have therapeutic relevance.

  • Series |

    Throughout 2008, a series of specially commissioned articles that examine hypoxia and metabolism in tumour biology will be published in Nature Reviews Cancer. Although hypoxia is not a new phenomenon, we now have a much greater understanding of the molecular links between hypoxic conditions and tumour development. Apart from driving angiogenesis, hypoxia is also linked with changes in cellular metabolism, an area that has become a hot topic in cancer research. A greater understanding of these closely related tumorigenic changes should prove fruitful in the pursuit of more effective cancer drugs.

  • Series |

    Throughout 2006 and 2007, a series of articles on the Tumour Microenvironment was published in Nature Reviews Cancer. The study of the tumour microenvironment involves a multidisciplinary approach, with in vitro and in vivo models of tumour growth, invasion, extracellular matrix remodelling, angiogenesis and inflammation, as well as preclinical trials, all contributing to the rapid progress that is being made in this area. We hope that this series of articles gave you a taste of the diversity of topics that form part of this rapidly moving field.