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This protocol extension describes the fabrication of optofluidic neural probes and implantation for advanced in vivo pharmacology and optogenetics in freely moving rodents.
Moreno-Romero et al. describe how to apply the INTACT method to purify endosperm nuclei from Arabidopsis. Purified nuclei can be used for ChIP-seq analysis or bisulfite sequencing.
Targeted DamID (TaDa) extends DamID to enable cell-type-specific profiling of genome-wide protein binding. Transcription factor binding sites, RNA Pol II occupancy and chromatin states can be studied to provide insights into cell-fate specification.