An atomic force microscope with antibodies attached to its tip can be used to determine methylation patterns in individual DNA strands by making hundreds of force spectroscopy measurements.
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Marszalek, P. Detecting methylation with force. Nature Nanotech 5, 765–766 (2010). https://doi.org/10.1038/nnano.2010.223
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DOI: https://doi.org/10.1038/nnano.2010.223
