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Chiral crystals are sought after for their ability to tune the polarization of light. Now, multiwalled boron nitride nanotubes (BNNTs) are shown to be promising chiral crystals with coherently stacked structures, wherein the component tubes display mono-chirality, homo-handedness and unipolarity. This unique architecture endows BNNTs with strong optical nonlinearity and a chiral geometry-dependent chiroptical response.
Combining single-molecule Förster resonance energy transfer (FRET) and fluorescence lifetime information inside an anti-Brownian electrokinetic (ABEL) trap makes it possible to distinguish dozens of biomolecules in a sample mixture. This method enables extensive barcoding of biomolecules with a minimal set of chemical components and opens up a path toward biomolecule quantification in complex mixtures.
By combining fibre-based trapping and position detection with cold damping through planar electrodes, cooling of a silica nanoparticle particle motion to a few hundred phonons on a chip is achieved.
Multiwalled boron nitride nanotubes, featuring coherently stacked structures with monochirality, homo-handedness and unipolarity among the component tubes, show a large nonlinear chiroptical response.
Nanocarrier delivery has huge potential in agriculture; however, there are significant scientific and societal barriers to overcome. In this Review, the authors explore the state of the field, what lessons can be learned from nanomedicine, and discuss what scientific and societal issues need to be addressed.
Nanowires enable efficient genetic engineering of non-activated naive T cells, providing a technological platform for the generation of gene-modified T cells with maximal therapeutic efficacy.
Ischaemic heart disease, which poses a severe threat to human health, is characterized by mitochondria damage and energy metabolism disorder. Here mitochondria were orally transplanted to the heart using nanomotors to restore energy metabolism by non-invasive administration.
This paper presents a virus-like lipid nanoparticle decorated with spike proteins capable of carrying antigens, including mRNA and proteins, for vaccination against SARS-CoV-2 variants.
The ability to genetically modify haematopoietic stem cells would allow the durable treatment of a diverse range of genetic disorders but gene delivery to the bone marrow has not been achieved. Here lipid nanoparticles that target and deliver mRNA to 14 unique cells within the bone marrow are presented.
Atomic force microscopy (AFM) is coupled with time-domain two-dimensional infrared (2DIR) spectroscopy to develop AFM-2DIR nanospectroscopy, which combines the spatial precision of AFM with the rich spectroscopic information provided by 2DIR spectroscopy. Application of this method reveals the anharmonicity of a carbonyl vibrational mode and the possible energy transfer pathways of hyperbolic phonon polaritons in isotope-rich hexagonal boron nitride.
Advances in nanoscale engineering bring us closer to unlocking the full potential of perovskite light-emitting diodes for future lighting and display applications.
A single monolayer semiconductor integrated into a plasmonic tunnel junction exhibits electroluminescence with photon energies that exceed the excitation electron potential. This phenomenon is shown to be indirectly triggered by inelastically tunnelling electrons.
FRETfluors—nanostructures with Cy3 and Cy5 dyes and a DNA scaffold—are used to generate distinct spectroscopic signals from different configurations and mixtures of mRNA, dsDNA and proteins in an anti-Brownian electrokinetic trap for single-molecule multiplexed sensing.
Integrating atomic force microscopy with time-domain two-dimensional infrared spectroscopy provides insights into molecular structures, mode coupling and energy transfers with high spatial resolution.
Superionic fluoride dielectrics with a low ion migration barrier are capable of excellent capacitive coupling and are highly compatible with scalable device manufacturing processes for integrated electronics.
This analysis leverages a large-scale literature review, text mining, statistics and machine learning to identify trends, shortcomings and future opportunities in developing and deploying inorganic nanoparticles for cancer diagnosis and therapy.
Antibacterial action, along with restoration of redox and immune homeostasis, is achieved using a lipid–nanozyme hybrid for the healing of diabetic foot ulcers.
Therapies for treating bacterial infection and increasing wound healing are needed. Here the authors report a liposozyme that combines reactive oxygen species generation and scavenging for antibacterial action and modulation of redox and immune homeostasis, increasing wound healing.
Increased nutrient uptake of cancer cells offers a possible therapeutic target. Here, the authors designed a nanoparticle to deliver phenylboronic-acid-modified cholesterol which reacts in cancer cells to trigger Gaucher disease-like metabolic damage to tumour cells, demonstrating potential application.
