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A CRISPR–Cas9-based gene drive array platform is developed and combined with mating-competent Candida albicans haploids to generate homozygous double-deletion mutants, transforming our ability to do genetic interaction analyses in fungi.
The crystal structure of MlaA, coupled with simulations of its interaction with phospholipids, elucidates how this outer membrane lipoprotein acts as a phospholipid translocation channel to maintain the asymmetric composition of the outer membrane.
Bacillus subtilis cells are able to sense self-produced autoinducers, which gives rise to stronger quorum-sensing-mediated responses, in a process that can influence the generation of persisters during antibiotic treatment.
Comparative genomics and high-resolution mass spectrometry reveal the biosynthetic gene clusters, and vast chemical diversity of natural products that they encode, in Photorhabdus and Xenorhabdus, bacteria that interact with hosts as symbionts and entomopathogens.
Under nutritional limitation, modification of the Lactobacillus plantarum cell wall by d-alanylation of teichoic acids is important for host intestinal peptidase expression and consequently growth of the Drosophila host, providing further insights into host–commensal interactions.
An atomic model for a type 2 secretion system pseudopilus from Klebsiella oxytoca reveals a comprehensive network of inter-subunit contacts while mutational and functional analyses highlight the role of calcium in PulG folding and stability.
The main targets of Zika virus infection in human peripheral blood mononuclear cells are monocytes, particularly CD14+CD16+ monocytes, which are expanded in Zika patients and in in vitro-infected samples.
In situ sampling reveals that members of the SAR11 clade show significantly lower retention by mucous filter feeders, and that this is probably due to their reduced hydrophobic cell surface, suggesting that cell surface properties are important factors in predator–prey interactions.
The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.
Levulinic acid (LA) is a value-added chemical easily obtained from biomass. The pathway enabling LA degradation in Pseudomonas putida requires five enzymes and can be engineered into Escherichia coli, which could enable further biotechnological applications.
Infection of the alga Emiliania huxleyi with its virus EhV results in the increased release of extracellular vesicles that impact viral decay and infection, suggesting that EhV exploits these extracellular vesicles for efficient viral infection during algal blooms.
Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant (rPpMUT) that is effective against T.b. gambiense infection in mice, suggesting that it may serve as a therapy against sleeping sickness.
LysM, the lysis protein of the Escherichia coli levivirus M, represents a new ‘protein antibiotic’ that interferes with the synthesis of peptidoglycan by inhibiting lipid II flipping.
The recovery of 7,903 bacterial and archaeal metagenome-assembled genomes increases the phylogenetic diversity represented by public genome repositories and provides the first representatives from 20 candidate phyla.