Review abstract


Nature Methods 7, S16 - S25 (2010)
doi:10.1038/nmeth.1434

Visualization of multiple alignments, phylogenies and gene family evolution

James B Procter1, Julie Thompson2, Ivica Letunic3, Chris Creevey4, Fabrice Jossinet5 & Geoffrey J Barton1


Software for visualizing sequence alignments and trees are essential tools for life scientists. In this review, we describe the major features and capabilities of a selection of stand-alone and web-based applications useful when investigating the function and evolution of a gene family. These range from simple viewers, to systems that provide sophisticated editing and analysis functions. We conclude with a discussion of the challenges that these tools now face due to the flood of next generation sequence data and the increasingly complex network of bioinformatics information sources.

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  1. School of Life Sciences Research, College of Life Sciences, University of Dundee, Dundee, UK.
  2. Institute of Genetics and Molecular and Cellular Biology (IGBMC), Strasbourg, France.
  3. European Molecular Biology Laboratory, Heidelberg, Germany.
  4. Animal Bioscience Centre, Teagasc, Ireland.
  5. Architecture et réactivité de l'ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique (CNRS), Strasbourg, France.

Correspondence to: James B Procter1 e-mail: j.procter@dundee.ac.uk



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