Barcoded semisynthetic nucleosomes combined with massively parallel sequencing provide an innovative new platform for analyzing the histone-recognition and histone-modifying activities of chromatin-associated proteins.
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References
Nguyen, U.T.T. et al. Nat. Methods 11, 834–840 (2014).
Brownell, J.E. et al. Cell 84, 843–851 (1996).
Taunton, J., Hassig, C.A. & Schreiber, S.L. Science 272, 408–411 (1996).
Dhalluin, C. et al. Nature 399, 491–496 (1999).
Kim, J. et al. EMBO Rep. 7, 397–403 (2006).
Shi, X. et al. J. Biol. Chem. 282, 2450–2455 (2007).
Maze, I., Noh, K.M., Soshnev, A.A. & Allis, C.D. Nat. Rev. Genet. 15, 259–271 (2014).
Ruthenburg, A.J. et al. Cell 145, 692–706 (2011).
Fuchs, S.M. & Strahl, B.D. Epigenomics 3, 247–249 (2011).
Filippakopoulos, P. et al. Cell 149, 214–231 (2012).
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Shanle, E., Rothbart, S. & Strahl, B. Chromatin biochemistry enters the next generation of code 'seq-ing'. Nat Methods 11, 799–800 (2014). https://doi.org/10.1038/nmeth.3044
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DOI: https://doi.org/10.1038/nmeth.3044