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A special Focus (beginning on p. 781) on mass spectrometry in proteomics applications is intended to inspire more cell biologists to take advantage of this powerful technology.
Mass spectrometry has been rapidly maturing as the core technology at the heart of proteomics. The application of these powerful methods to the study of human diseases and their translation to the clinic, however, has been beset with unique challenges.
PCR—the workhorse of modern molecular biology—is charging forward using both conventional and digital methods to explore single cells and even single molecules. Nathan Blow reports.