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The protein microscope: incorporating mass spectrometry into cell biology

Nature Methods volume 4, pages 783–784 (2007)Cite this article

Abstract

Mass spectrometry has come into its own as an extremely powerful tool for the study of whole proteomes. So why are not more cell biologists embracing it with open arms?

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References

  1. Au, C.E. et al. Curr. Opin. Cell Biol. 19, 376–385 (2007).

    Article  CAS  Google Scholar 

  2. Yates, J.R. III, Gilchrist, A., Howell, K.E. & Bergeron, J.J. Nat. Rev. Mol. Cell Biol. 6, 702–714 (2005).

    Article  CAS  Google Scholar 

  3. Collins, S.R. et al. Mol. Cell. Proteomics 6, 439–450 (2007).

    Article  CAS  Google Scholar 

  4. Cronshaw, J.M., Krutchinsky, A.N., Zhang, W., Chait, B.T. & Matunis, M.J. J. Cell Biol. 158, 915–927 (2002).

    Article  CAS  Google Scholar 

  5. Pennisi, E. Science 316, 1113 (2007).

    Article  CAS  Google Scholar 

  6. Blondeau, F. et al. Proc. Natl. Acad. Sci. USA 101, 3833–3838 (2004).

    Article  CAS  Google Scholar 

  7. Gilchrist, A. et al. Cell 127, 1265–1281 (2006).

    Article  CAS  Google Scholar 

  8. Takamori, S. et al. Cell 127, 831–846 (2006).

    Article  CAS  Google Scholar 

  9. Simpson, J.C. & Pepperkok, R. Genome Biol. 7, 222 (2006).

    Article  Google Scholar 

  10. Zhang, Z. & Chan, D.W. Cancer Epidemiol. Biomarkers Prev. 14, 2283–2286 (2005).

    Article  CAS  Google Scholar 

  11. Zubarev, R. & Mann, M. Mol. Cell. Proteomics 6, 377–381 (2007).

    Article  CAS  Google Scholar 

  12. Elias, J.E., Haas, W., Faherty, B.K. & Gygi, S.P. Nat. Methods 2, 667–675 (2005).

    Article  CAS  Google Scholar 

  13. Bencsath-Makkai, Z. et al. Conf. Proc. IEEE Eng. Biol. Soc. 4, 3567–3570 (2003).

    Article  Google Scholar 

  14. Bergeron, J.J. & Hallett, M. Nat. Biotechnol. 25, 61–62 (2007).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge support by the Canadian Institutes for Health Research, Canada Foundation for Innovation, Natural Sciences and Engineering Research Council of Canada, Genome Quebec and Genome Canada, McGill University, Göteborg University, the Swedish Research Council and the Knut and Alice Wallenberg foundation. We thank A. Gilchrist, C. Au and Z. Bencsath-Makkai for help with this manuscript.

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Author notes

  1. Alexander W Bell, Tommy Nilsson and Robert E Kearney: Alexander W. Bell and Tommy Nilsson contributed equally to this work.

Authors and Affiliations

  1. Alexander W. Bell and John J.M. Bergeron are at the Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 2B2, Canada. john.bergeron@mcgill.ca,

    Alexander W Bell & John J M Bergeron

  2. Tommy Nilsson is at the Department of Medical and Clinical Genetics, Institute of Biomedicine and the Proteomics Centre at the Sahlgrenska Academy, Göteborg University, 413 90 Göteborg, Sweden.,

    Tommy Nilsson

  3. Robert E. Kearney is at the Department of Biomedical Engineering, McGill University, Montreal, Quebec H3A 2B4, Canada.,

    Robert E Kearney

Authors
  1. Alexander W Bell
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  2. Tommy Nilsson
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  3. Robert E Kearney
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  4. John J M Bergeron
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Bell, A., Nilsson, T., Kearney, R. et al. The protein microscope: incorporating mass spectrometry into cell biology. Nat Methods 4, 783–784 (2007). https://doi.org/10.1038/nmeth1007-783

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