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When we see the results of clinical trials, we look unwittingly at a drama in which the desperation and hopes of the research subjects are only present in the codification of the results. Consequently, it is easy to overlook the suffering of those involved and to feel little sympathy for them. The advent of AIDS has meant that many aspects of medical practice, including the design of clinical trials, are being scrutinized with renewed vigor.
Solid tumors in mice treated with several cycles of the angiogenesis inhibitor endostatin regress, do not develop drug resistance, and eventually fail to recur.
Mutations in a homeodomain transcription factor that controls photoreceptor differentiation cause Cone-Rod Dystrophy, an inherited disease of retinal degeneration that results in blindness.
Soluble Fas ligand is a less potent inducer of poptosis than its membrane-bound form, and may be a mediator of inflammation as well as a death agonist (pages 31–36).
A candidate gene, cg2, is implicated in resistance to chloroquine in Plasmodium falciparum malaria parasites, but the mechanism of resistance remains unclear.
