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Understanding cancer from the stem cells up

Nature Medicine volume 23, pages 656–657 (2017)Cite this article

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A new study that uses an integrated single-cell transcriptomics approach to characterize cancer stem cell populations during treatment with molecularly targeted therapies offers insights into disease evolution and points to new therapeutic targets.

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Figure 1: The dynamics of cancer stem cell selection and evolution on targeted therapy.

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Authors and Affiliations

  1. and in the Division of Hematology and Medical Oncology, Christopher A. Eide and Brian J. Druker are at the Howard Hughes Medical Institute Portland, Oregon, USA, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.,

    Christopher A Eide & Brian J Druker

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  1. Christopher A Eide
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  2. Brian J Druker
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Correspondence to Brian J Druker.

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Competing interests

B.J.D. is currently principal investigator or co-investigator on Novartis and Bristol-Myers Squibb clinical trials. His institution, OHSU, has contracts with these companies to pay for patient costs, nurse and data-manager salaries, and institutional overhead. He does not derive a salary, and his lab does not receive funds from these contracts. OHSU and B.J.D. have a financial interest in MolecularMD, a company that may have a commercial interest in this research and technology. This potential individual and institutional conflict of interest has been reviewed and managed by OHSU.

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Eide, C., Druker, B. Understanding cancer from the stem cells up. Nat Med 23, 656–657 (2017). https://doi.org/10.1038/nm.4353

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