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Volume 8 Issue 4, April 2007

Most people infected with human immunodeficiency virus 2 (HIV-2), shown here as orange virions, do not progress to AIDS. Rowland-Jones and Whittle discuss HIV-2 pathogenesis and what it can teach about protective immunity to HIV-1 (p 329). Artwork by Lewis Long.

Volume 8 Issue 4

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  • The transcriptional regulators Foxp3 and Aire have key functions in self-tolerance. New studies emphasize potential links between Aire-expressing thymic stromal cells and the development of Foxp3-expressing regulatory T cells.

    • Takashi Nomura
    • Shimon Sakaguchi
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  • Alloreactive T cell responses are considered the product of 'degenerate' recognition by T cells of many different complexes of peptide and major histocompatibility complex. New work shows instead that T cell receptor alloresponses are highly 'polyspecific' for such complexes.

    • Janko Nikolich-Žugich
    News & Views

  • Limited niche availability restricts the number of long-lived plasma cells that can reside in the bone marrow. New research describes homeostatic regulatory mechanisms that allow newly 'minted' plasma cells to gain entry to such niches.

    • Jeffrey V Ravetch
    • Michel Nussenzweig
    News & Views

  • Recruitment of lymphocytes to the lymph nodes requires L-selectin-mediated recognition of carbohydrate determinants presented by O-glycans. New work shows that N-glycans 'decorated' with the same determinants also contribute to lymphocyte homing.

    • Ronen Alon
    • Steven Rosen
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