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Volume 4 Issue 7, July 2003

The control of DNA accessibility is a theme throughout our Focus on Chromatin Dynamics (pages 601–639; free online until the end of September 2003). Like the intricate braids of Leda as sketched by Leonardo da Vinci, chromatin has various states. Heterochromatin is as inaccessible as tightly coiled braids (1), loose curls (2) represent more accessible DNA, and untwined strands (3) resemble the opened templates necessary for replication or transcription into RNA (4). [Original image © Alinari Archives/CORBIS]

Volume 4 Issue 7

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  • The identification of BLTA and its ligand B7x adds to the growing list of negative costimulatory molecules that can dampen the adaptive immune response.

    • Anthony J Coyle
    • Jose-Carlos Gutierrez-Ramos
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  • The anti-influenza CD8+ T cell response in HLA-A2 adults is dominated by a specific TCR. The crystal structure of the TCR and peptide-MHC complex show unusual interactions that help to explain the molecular basis of this dominant TCR selection.

    • Mark M Davis
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  • CpG signaling through TLR9 elicits type 1 cytokine production, which can suppress IgE-associated hypersensitivity reactions. CpG also acts directly on B cells by inducing STAT1-independent T-bet expression.

    • Ian R Rifkin
    • Ann Marshak-Rothstein
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  • A family of intracellular molecules called NODs has been proposed to sense bacteria within the cell. New data now show that NOD1 senses a distinct bacterial component and may thus be important in responding to bacteria with this molecular signature.

    • Koichi S Kobayashi
    • Elizabeth E Eynon
    • Richard A Flavell
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  • A comprehensive overview and four review articles that demystify the molecular mechanisms underlying lymphocytes' unique recombination events and specific gene expression programs.

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