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Volume 4 Issue 8, August 2003

A thymus section in the style of Vincent Van Gogh (1853-1890). Fowlkes and colleagues show that by increasing the number of CD4+CD8+ thymocytes that cannot be selected in a given microenvironment, lineage commitment can be redirected. Confocal micrograph by Matilde Canelles; art by Lewis Long.

Volume 4 Issue 8

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  • Characterization of the interaction between purified Spätzle and Toll shows that cleaved Spätzle dimers directly bind Toll and trigger intracellular signaling.

    • David Underhill
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  • Rap1 mediates 'inside-out' signaling from the T cell receptor to LFA-1. The discovery of RAPL, a Rap1-binding molecule, helps explain how Rap1 induces T cell adhesion.

    • Robert T Abraham
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  • Commitment by thymocytes to a CD4 or a CD8 lineage depends on T cell receptor–mediated intracellular signaling cues. But new data indicate that T cell lineage fate may also be influenced by the frequency of nonselected cells in the thymic microenvironment during development.

    • Pamela J Fink
    News & Views

  • Nef-expressing macrophages induce activation of resting T lymphocytes, permitting productive HIV-1 infection. A recent report in Nature defines just how Nef manipulates macrophage signaling to enhance T cell infectivity.

    • Melissa Pope
    News & Views
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