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RNA-binding proteins, the guardians of the marginal zone

Nature Immunology volume 18, pages 595–597 (2017)Cite this article

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RNA-binding proteins (RBPs) take control of binary cell-fate 'decisions' and cellular identity in lymphoid organs, as the RBP ZFP36L1 is shown to negatively regulate the stability of the transcription factors KLF2 and IRF8 to control the maintenance, survival and localization of marginal zone B cells.

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Figure 1: ZFP36L1 regulates the survival and localization of MZ B cells.

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Authors and Affiliations

  1. Beatriz Aranda-Orgilles and Iannis Aifantis are in the Department of Pathology, Palaniraja Thandapan,

    Palaniraja Thandapani, Beatriz Aranda-Orgilles & Iannis Aifantis

  2. Laura & Isaac Perlmutter Cancer Center, and Helen L. & Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York, USA.,

    Palaniraja Thandapani, Beatriz Aranda-Orgilles & Iannis Aifantis

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  1. Palaniraja Thandapani
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  2. Beatriz Aranda-Orgilles
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  3. Iannis Aifantis
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Correspondence to Iannis Aifantis.

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Thandapani, P., Aranda-Orgilles, B. & Aifantis, I. RNA-binding proteins, the guardians of the marginal zone. Nat Immunol 18, 595–597 (2017). https://doi.org/10.1038/ni.3752

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