Advances in human genomics, when validated functionally, can lead to new insights into how the immune system works. Notably, previously unknown mechanisms revealed by genomics can lead to the development of precision medicine unanticipated on the basis of phenotype alone.
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References
Conley, M.E. & Casanova, J.L. Curr. Opin. Immunol. 30, 17–23 (2014).
Al-Herz, W. et al. Front Immunol. 5, 162 (2014).
Pascual, V., Chaussabel, D. & Banchereau, J. Annu. Rev. Immunol. 28, 535–571 (2010).
Xue, Y. et al. Am. J. Hum. Genet. 91, 1022–1032 (2012).
Price, S. et al. Blood 123, 1989–1999 (2014).
Lo, B. et al. J. Clin. Immunol. 33, 479–488 (2013).
Boisson, B., Quartier, P. & Casanova, J.L. Curr. Opin. Immunol. 32, 90–105 (2015).
Lu, W. et al. Cell 159, 1578–1590 (2014).
Angulo, I. et al. Science 342, 866–871 (2013).
Lucas, C.L. et al. Nat. Immunol. 15, 88–97 (2014).
Fisher, G.H. et al. Cell 81, 935–946 (1995).
Siegel, R.M. et al. Science 288, 2354–2357 (2000).
Oftedal, B.E. et al. Immunity 42, 1185–1196 (2015).
Rieux-Laucat, F. & Casanova, J.L. Science 345, 1560–1561 (2014).
Waterhouse, P. et al. Science 270, 985–988 (1995).
Kuehn, H.S. et al. Science 345, 1623–1627 (2014).
Noguchi, M. et al. Cell 73, 147–157 (1993).
Bennett, C.L. et al. Nat. Genet. 27, 20–21 (2001).
Chaigne-Delalande, B. et al. Science 341, 186–191 (2013).
Li, F.Y. et al. Nature 475, 471–476 (2011).
Holzelova, E. et al. N. Engl. J. Med. 351, 1409–1418 (2004).
Schubert, D. et al. Nat. Med. 20, 1410–1416 (2014).
Jing, H. et al. J. Allergy Clin. Immunol. 133, 1667–1675 (2014).
Bustamante, J. et al. Semin. Immunol. 26, 454–470 (2014).
Milner, J.D. et al. Nature 452, 773–776 (2008).
Flanagan, S.E. et al. Nat. Genet. 46, 812–814 (2014).
Milner, J.D. et al. Blood 125, 591–599 (2015).
Haapaniemi, E.M. et al. Blood 125, 639–648 (2015).
Boisson-Dupuis, S. et al. Curr. Opin. Immunol. 24, 364–378 (2012).
Lo, B. et al. Science 349, 436–440 (2015).
Zhang, Y. et al. J. Allergy Clin. Immunol. 133, 1400–1409 (2014).
Sassi, A. et al. J. Allergy Clin. Immunol. 133, 1410–1419 (2014).
Stray-Pedersen, A. et al. Am. J. Hum. Genet. 95, 96–107 (2014).
Lupski, J.R. et al. Cell 147, 32–43 (2011).
Wu, J. et al. J. Clin. Invest. 98, 1107–1113 (1996).
Oliveira, J.B. et al. Proc. Natl. Acad. Sci. USA 104, 8953–8958 (2007).
Ciancanelli, M.J. et al. Science 348, 448–453 (2015).
MacArthur, D.G. et al. Nature 508, 469–476 (2014).
Casanova, J.L. et al. J. Exp. Med. 211, 2137–2149 (2014).
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Supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (US National Institutes of Health).
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Zhang, Y., Su, H. & Lenardo, M. Genomics is rapidly advancing precision medicine for immunological disorders. Nat Immunol 16, 1001–1004 (2015). https://doi.org/10.1038/ni.3275
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DOI: https://doi.org/10.1038/ni.3275
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