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You break it, you fix it: functions for AID downstream of deamination

Nature Immunology volume 14, pages 1112–1114 (2013)Cite this article

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In a phosphorylation-dependent positive feedback loop, the cytidine deaminase AID amplifies the generation of double-strand DNA breaks, which shows it can also function downstream of deamination.

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Figure 1: Two roles for AID during CSR.

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Authors and Affiliations

  1. Rebecca K. Delker is with the Laboratory of Lymphocyte Biology, The Rockefeller University, New York, New York, USA, and The Rockefeller Graduate Program, The Rockefeller University, New York, New York, USA.,

    Rebecca K Delker

  2. F. Nina Papavasiliou is with the Laboratory of Lymphocyte Biology, The Rockefeller University, New York, New York, USA.,

    F Nina Papavasiliou

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  1. Rebecca K Delker
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  2. F Nina Papavasiliou
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Correspondence to F Nina Papavasiliou.

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The authors declare no competing financial interests.

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Delker, R., Papavasiliou, F. You break it, you fix it: functions for AID downstream of deamination. Nat Immunol 14, 1112–1114 (2013). https://doi.org/10.1038/ni.2738

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