Direct evaluation of the contribution of somatic hypermutation (SHM) to mucosal immunity has been hampered by the lack of models able to dissociate SHM from class-switch recombination, which are both dependent on the cytidine deaminase AID. A new mouse AID model now demonstrates the critical role of SHM in the control of gut bacteria.
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Chen, K., Cerutti, A. AIDing the pursuit of IgA diversity. Nat Immunol 12, 197–198 (2011). https://doi.org/10.1038/ni0311-197
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DOI: https://doi.org/10.1038/ni0311-197