Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

AIMing 2 defend against intracellular pathogens

Nature Immunology volume 11, pages 367–369 (2010)Cite this article

Subjects

Intracellular pathogens face a diverse array of innate immune receptors. New data show that a single receptor, AIM2, functions to detect bacterial or viral DNA in the cytosol, inducing a protective inflammasome response.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Endosomal and cytosolic pathways for pathogen detection.

Kim Caesar

References

  1. Martinon, F., Mayor, A. & Tschopp, J. Annu. Rev. Immunol. 27, 229–265 (2009).

    Article  CAS  Google Scholar 

  2. Roberts, T.L. et al. Science 323, 1057 (2009).

    Article  CAS  Google Scholar 

  3. Burckstummer, T. et al. Nat. Immunol. 10, 266 (2009).

    Article  Google Scholar 

  4. Hornung, V. et al. Nature 458, 514 (2009).

    Article  CAS  Google Scholar 

  5. Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J. & Alnemri, E.S. Nature 458, 509 (2009).

    Article  CAS  Google Scholar 

  6. Fernandes-Alnemri, T. et al. Nat. Immunol. 11, 385–393 (2010).

    Article  CAS  Google Scholar 

  7. Rathinam, V.A.K. et al. xNat. Immunol. 11, 395–402 (2010).

    Article  CAS  Google Scholar 

  8. Mariathasan, S., Weiss, D.S., Dixit, V.M. & Monack, D.M. J. Exp. Med. 202, 1043–1049 (2005).

    Article  CAS  Google Scholar 

  9. Henry, T., Brotcke, A., Weiss, D.S., Thompson, L.J. & Monack, D.M. J. Exp. Med. 204, 987–994 (2007).

    Article  CAS  Google Scholar 

  10. Heit, A. et al. J. Immunol. 170, 2802–2805 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Arthur M. Krieg is with Pfizer, Cambridge, Massachusetts, USA.,

    Arthur M Krieg

Authors
  1. Arthur M Krieg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arthur M Krieg.

Ethics declarations

Competing interests

The author declares competing financial interests: details accompany the full-text HTML version of the paper at http://www.nature.com/natureimmunology/.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krieg, A. AIMing 2 defend against intracellular pathogens. Nat Immunol 11, 367–369 (2010). https://doi.org/10.1038/ni0510-367

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0510-367

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing