Nature Immunology - CURRENT ISSUE : August 2008 - Vol 9 No 8
LATEST HIGHLIGHTS
Article of the Month
Essential for antigen-driven T cell responses, the cortactin homolog HS1 may also influence natural killer cell biology. Butler and colleagues identify functions for cortactin in natural killer cell cytotoxicity, adhesion and chemotaxis.
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News & Views by Beemiller & KrummelADVANCE ONLINE PUBLICATION
The function of the adaptor protein TRADD is uncertain. Teams led by Pasparakis and Liu solidify TRADD's function in TNF receptor signaling and extend its influence to TRIF-dependent Toll-like receptor pathways.
CURRENT ISSUE
ERAAP in anti-parasite responses
Article by BlanchardThe Toxoplasma gondii peptides recognized by protective CD8+ T cells remain uncharacterized. Shastri and colleagues identify an immunodominant T. gondii peptide generated by a mechanism dependent on the endoplasmic reticulum aminopeptidase ERAAP.
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News & Views by Delgado & JensenCURRENT ISSUE
Arrestin NK cells
Article by YuInhibitory receptors antagonize natural killer cell cytotoxicity. Ge and colleagues show that the scaffold protein β-arrestin 2 recruits the phosphatases SHP-1 and SHP-2 to the inhibitory receptor KIR2DL1 to enhance 'downstream' inhibitory signaling.
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News & Views by Bryceson & LjunggrenCURRENT ISSUE
Defense by autophagy
Article by YanoWhether autophagy affects host survival during intracellular bacteria infection is unclear. Kurata and colleagues find that autophagy initiated by the pattern-recognition receptor PGRP-LE promotes survival of drosophila after Listeria monocytogenes infection.
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News & Views by VirginANNOUNCEMENT
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