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Walking the AID tightrope

The mutator activation-induced cytidine deaminase is essential for immunoglobulin diversification but can be detrimental in other settings. A new comprehensive analysis investigates how its gene expression is regulated.

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Figure 1: A balance of silencers and activators regulates AID expression.

References

  1. Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A. & Honjo, T. Adv. Immunol. 94, 1–36 (2007).

    Article  CAS  Google Scholar 

  2. Okazaki, I.M., Kotani, A. & Honjo, T. Adv. Immunol. 94, 245–273 (2007).

    Article  CAS  Google Scholar 

  3. Tran, T.H. et al. Nat. Immunol. 11, 148–154 (2010).

    Article  CAS  Google Scholar 

  4. Delker, R.K., Fugmann, S.D. & Papavasiliou, F.N. Nat. Immunol. 10, 1147–1153 (2009).

    Article  CAS  Google Scholar 

  5. Liu, M. & Schatz, D.G. Trends Immunol. 30, 173–181 (2009).

    Article  Google Scholar 

  6. Pasqualucci, L. et al. Nat. Genet. 40, 108–112 (2008).

    Article  CAS  Google Scholar 

  7. Robbiani, D.F. et al. Cell 135, 1028–1038 (2008).

    Article  CAS  Google Scholar 

  8. Wang, J.H. et al. Nature 460, 231–236 (2009).

    Article  CAS  Google Scholar 

  9. Dedeoglu, F., Horwitz, B., Chaudhuri, J., Alt, F.W. & Geha, R.S. Int. Immunol. 16, 395–404 (2004).

    Article  CAS  Google Scholar 

  10. Yadav, A. et al. Mol. Immunol. 43, 529–541 (2006).

    Article  CAS  Google Scholar 

  11. Park, S.R. et al. Nat. Immunol. 10, 540–550 (2009).

    Article  CAS  Google Scholar 

  12. Sayegh, C.E., Quong, M.W., Agata, Y. & Murre, C. Nat. Immunol. 4, 586–593 (2003).

    Article  CAS  Google Scholar 

  13. Gonda, H. et al. J. Exp. Med. 198, 1427–1437 (2003).

    Article  CAS  Google Scholar 

  14. Crouch, E.E. et al. J. Exp. Med. 204, 1145–1156 (2007).

    Article  CAS  Google Scholar 

  15. Petersen-Mahrt, S.K., Coker, H.A. & Pauklin, S. J. Mol. Med. 87, 893–897 (2009).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Jayanta Chaudhuri.

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Lee-Theilen, M., Chaudhuri, J. Walking the AID tightrope. Nat Immunol 11, 107–109 (2010). https://doi.org/10.1038/ni0210-107

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