Focus on Immune Signaling Cross Talk

Embrace the complexity - p325

doi:10.1038/ni0409-325

Immune cell signal transduction is just too complicated to be effectively queried using traditional methods and mindsets.

Full Text - Embrace the complexity | PDF (215 KB) - Embrace the complexity

Focus on Immune Signaling Cross Talk

Navigating the network: signaling cross-talk in hematopoietic cells - pp327 - 331

Iain D C Fraser & Ronald N Germain

doi:10.1038/ni.1711

Abstract - | Full Text - Navigating the network: signaling cross-talk in hematopoietic cells | PDF (531 KB) - Navigating the network: signaling cross-talk in hematopoietic cells

Focus on Immune Signaling Cross Talk

Integration of cytokine and heterologous receptor signaling pathways - pp333 - 339

Jelena S Bezbradica & Ruslan Medzhitov

doi:10.1038/ni.1713

Abstract - | Full Text - Integration of cytokine and heterologous receptor signaling pathways | PDF (1,244 KB) - Integration of cytokine and heterologous receptor signaling pathways

Focus on Immune Signaling Cross Talk

Cross-regulation of signaling by ITAM-associated receptors - pp340 - 347

Lionel B Ivashkiv

doi:10.1038/ni.1706

Abstract - | Full Text - Cross-regulation of signaling by ITAM-associated receptors | PDF (508 KB) - Cross-regulation of signaling by ITAM-associated receptors

Focus on Immune Signaling Cross Talk

Death receptor signal transducers: nodes of coordination in immune signaling networks - pp348 - 355

Nicholas S Wilson, Vishva Dixit & Avi Ashkenazi

doi:10.1038/ni.1714

Abstract - | Full Text - Death receptor signal transducers: nodes of coordination in immune signaling networks | PDF (672 KB) - Death receptor signal transducers: nodes of coordination in immune signaling networks

Focus on Immune Signaling Cross Talk

Selectivity and therapeutic inhibition of kinases: to be or not to be? - pp356 - 360

Kamran Ghoreschi, Arian Laurence & John J O'Shea

doi:10.1038/ni.1701

Abstract - | Full Text - Selectivity and therapeutic inhibition of kinases: to be or not to be? | PDF (470 KB) - Selectivity and therapeutic inhibition of kinases: to be or not to be?

Focus on Immune Signaling Cross Talk

Lymphocyte signaling: beyond knockouts - pp361 - 364

Alexander Saveliev & Victor L J Tybulewicz

doi:10.1038/ni.1709

Abstract - | Full Text - Lymphocyte signaling: beyond knockouts | PDF (428 KB) - Lymphocyte signaling: beyond knockouts

Focus on Immune Signaling Cross Talk

Research Highlights - p365

doi:10.1038/ni0409-365

Full Text - Research Highlights | PDF (288 KB) - Research Highlights

AID and RPA: PKA makes the connection local - pp367 - 369

Cristina Rada

doi:10.1038/ni0409-367

How immunoglobulin gene loci are specifically targeted by activation-induced cytidine deaminase while the rest of the genome avoids potentially mutagenic events is becoming clearer.

Full Text - AID and RPA: PKA makes the connection local | PDF (822 KB) - AID and RPA: PKA makes the connection local

See also: Article by Vuong et al.

The road not taken: memory T cell fate 'decisions' - pp369 - 370

Leo Lefrançois & David Masopust

doi:10.1038/ni0409-369

Two papers published recently in Science exploit new transgenic mouse systems to explore the path that activated CD8⁺ T cells take on the way to memory differentiation.

Full Text - The road not taken: memory T cell fate 'decisions' | PDF (271 KB) - The road not taken: memory T cell fate 'decisions'

Revisiting the follicular helper T cell paradigm - pp371 - 372

Bernard Malissen

doi:10.1038/ni0409-371

Antibody responses are critical for host protection against many pathogens. By reporting what actually occurs in vivo, two new studies provide important clues about follicular helper T cells that are dedicated to providing help to B cells.

Full Text - Revisiting the follicular helper T cell paradigm | PDF (770 KB) - Revisiting the follicular helper T cell paradigm

See also: Article by Fazilleau et al. | Article by Reinhardt et al.

Research Highlights - p373

doi:10.1038/ni0409-373

Full Text - Research Highlights | PDF (123 KB) - Research Highlights

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding - pp375 - 384

Nicolas Fazilleau, Louise J McHeyzer-Williams, Hugh Rosen & Michael G McHeyzer-Williams

doi:10.1038/ni.1704

Efficient humoral immunity requires B cell–T cell interactions in lymphoid follicles. McHeyzer-Williams and colleagues show that CXCR5⁺ follicular helper T cells have T cell antigen receptors with higher affinity for antigen than do other responding effector helper T cells.

Abstract - | Full Text - The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding | PDF (1,296 KB) - The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding | Supplementary information

See also: News and Views by Malissen | Article by Reinhardt et al.

Cytokine-secreting follicular T cells shape the antibody repertoire - pp385 - 393

R Lee Reinhardt, Hong-Erh Liang & Richard M Locksley

doi:10.1038/ni.1715

High-affinity isotype-switched B cells arise in germinal centers. Locksley and colleagues show that follicular helper T cells are the main cytokine providers for GC B cells and thereby directly influence the ensuing antibody response.

Abstract - | Full Text - Cytokine-secreting follicular T cells shape the antibody repertoire | PDF (990 KB) - Cytokine-secreting follicular T cells shape the antibody repertoire | Supplementary information

See also: News and Views by Malissen | Article by Fazilleau et al.

Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses - pp394 - 402

Hideki Nakano, Kaifeng Lisa Lin, Manabu Yanagita, Chantal Charbonneau, Donald N Cook, Terutaka Kakiuchi & Michael D Gunn

doi:10.1038/ni.1707

Lymphocytes are typically recruited into lymph nodes via CCR7. Gunn and colleagues identify an 'inflammatory DC' subset that is recruited directly from the bloodstream through the use of CCR2 and that induces potent T helper type 1 priming.

Abstract - | Full Text - Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses | PDF (936 KB) - Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses | Supplementary information

Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids - pp403 - 411

João P Pereira, Jinping An, Ying Xu, Yong Huang & Jason G Cyster

doi:10.1038/ni.1710

The molecular mechanisms that govern B cell progenitor localization in bone marrow sinusoids are not understood. Cyster and colleagues demonstrate involvement of cannabinoid receptor 2 in retaining developing B cells in sinusoids.

Abstract - | Full Text - Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids | PDF (1,331 KB) - Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids | Supplementary information

CD98hc facilitates B cell proliferation and adaptive humoral immunity - pp412 - 419

Joseph Cantor, Cecille D Browne, Raphael Ruppert, Chloé C Féral, Reinhard Fässler, Robert C Rickert & Mark H Ginsberg

doi:10.1038/ni.1712

The function of the CD98hc transmembrane protein in adaptive immune responses has been unclear. Ginsberg and colleagues show that CD98hc is needed for B cell proliferation and subsequent plasma cell differentiation.

Abstract - | Full Text - CD98hc facilitates B cell proliferation and adaptive humoral immunity | PDF (827 KB) - CD98hc facilitates B cell proliferation and adaptive humoral immunity | Supplementary information

Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination - pp420 - 426

Bao Q Vuong, Mieun Lee, Shaheen Kabir, Cristina Irimia, Stephania Macchiarulo, G Stanley McKnight & Jayanta Chaudhuri

doi:10.1038/ni.1708

Immunoglobulin class-switch recombination requires activation-induced cytidine deaminase. Chaudhuri and colleagues show independent recruitment of protein kinase A to switch regions, where it phosphorylates this deaminase to promote class-switch recombination.

Abstract - | Full Text - Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination | PDF (617 KB) - Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination | Supplementary information

See also: News and Views by Rada

CD27 is a thymic determinant of the balance between interferon-- and interleukin 17–producing T cell subsets - pp427 - 436

Julie C Ribot, Ana deBarros, Dick John Pang, Joana F Neves, Victor Peperzak, Scott J Roberts, Michael Girardi, Jannie Borst, Adrian C Hayday, Daniel J Pennington & Bruno Silva-Santos

doi:10.1038/ni.1717

In peripheral lymphoid organs, T cells are a source of interleukin 17. Silva-Santos and colleagues find that production of interleukin 17 versus interferon- by T cells is inflexible and is determined in the thymus.

Abstract - | Full Text - CD27 is a thymic determinant of the balance between interferon-- and interleukin 17–producing T cell subsets | PDF (1,095 KB) - CD27 is a thymic determinant of the balance between interferon-- and interleukin 17–producing T cell subsets | Supplementary information

Function of C/EBP in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals - pp437 - 443

Vladimir Litvak, Stephen A Ramsey, Alistair G Rust, Daniel E Zak, Kathleen A Kennedy, Aaron E Lampano, Matti Nykter, Ilya Shmulevich & Alan Aderem

doi:10.1038/ni.1721

Toll-like receptors (TLRs) induce complex transcriptional responses. Aderem and colleagues use systems-biology approaches to show that three transcription factors, NF-B, ATF3 and C/EBP, work together to distinguish persistent versus transient TLR stimuli.

Abstract - | Full Text - Function of C/EBP in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals | PDF (586 KB) - Function of C/EBP in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals | Supplementary information