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In this Perspective, MacMicking and colleagues discuss the roles of interferon-induced guanylate-binding proteins in directing inflammasome responses and their effects on immunity to a wide variety of microbial pathogens.
In this Perspective, Chang and Pearce discuss recent progress in understanding how metabolic pathways control T cell function and how these pathways can be manipulated for therapeutic purposes.
Murray reviews how immune cells integrate information about external essential amino acids supplies and transfer signals to growth and activation pathways that dictate cell function.
Ginhoux and colleagues discuss how recent advances in macrophage development and functional diversity indicate a multidimensional concept of macrophage ontogeny, activation and function.
The persistence of HIV reservoirs remains a barrier to sustained virologic remission in HIV-infected individuals after antiretroviral therapy is discontinued. Fauci and colleagues discuss the therapeutic strategies aimed at eliminating or controlling the virus in the absence of ART.
TCR ligation activates multiple downstream pathways that lead to myriad functional outputs. Malissen and colleagues discuss how unbiased mass spectrometry using signaling hub 'bait' molecules, such as Lat, provides new insight into TCR signaling cascades.
Recent findings in the SIV-monkey model provide new evidence that stimulating effective CD8+ T cell immunity could provide protection. McMichael and Koff explore the path forward for optimizing such responses in humans.