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Volume 30 Issue 3, March 2002

Cover art: Knit DNA by Emily Poe, based on a double helix cable pattern by June Oshiro

Volume 30 Issue 3

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Editorial

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News & Views

  • Using immunological and cytological approaches, researchers are beginning to reveal the complex molecular components of transcriptionally inert, pericentric heterochromatin. A new study shows that histone modifications and a non-Xist RNA component have essential structural roles in maintaining the tight organization of this type of chromatin.

    • Scott D. Briggs
    • Brian D. Strahl
    News & Views

  • A new study shows that the majority of mice cloned from somatic cells die prematurely. Of the six dead clones analyzed, four exhibited extensive necrosis of the liver, two had tumors and all had pneumonia, suggestive of immune impairment. These latest cloning-associated phenotypes will facilitate a better understanding of the mechanisms underlying nuclear-transfer cloning in mammals.

    • Anthony C.F. Perry
    • Teruhiko Wakayama
    News & Views

  • Meiotic silencing by unpaired DNA is a new mechanism, related to other homology-dependent gene silencing phenomena, with implications not only for genome protection against invasive nucleic acids but for genome maintenance and speciation as well.

    • Carlo Cogoni
    News & Views

  • The gene whose mutation results in autosomal recessive polycystic kidney disease has been identified, marking the end of a vigorous search and the beginning of a new phase of research toward understanding the molecular pathogenesis of the disorder.

    • Thomas M. Coffman
    News & Views
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