Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Untimely ends and new beginnings in mouse cloning

Nature Genetics volume 30, pages 243–244 (2002)Cite this article

A new study shows that the majority of mice cloned from somatic cells die prematurely. Of the six dead clones analyzed, four exhibited extensive necrosis of the liver, two had tumors and all had pneumonia, suggestive of immune impairment. These latest cloning-associated phenotypes will facilitate a better understanding of the mechanisms underlying nuclear-transfer cloning in mammals.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Wakayama, T., Perry, A.C.F., Zuccotti, M., Johnson, K.R. & Yanagimachi, R. Nature 394, 369–374 (1998).

    Article  CAS  Google Scholar 

  2. Inoue, K. et al. Science 295, 297 (2002).

    Article  CAS  Google Scholar 

  3. Wakayama, T. & Yanagimachi, R. Nature Genet. 22, 127–128 (1999).

    Article  CAS  Google Scholar 

  4. Wakayama, T. et al. Nature 407, 318–319 (2000).

    Article  CAS  Google Scholar 

  5. Tamashiro, K.L.K., Wakayama, T., Blanchard, R.J., Blanchard, D.C. & Yanagimachi, R. Biol. Reprod. 63, 328–334 (2000).

    Article  CAS  Google Scholar 

  6. Ogonuki, N. et al. Nature Genet. 30, 253–254 (2002).

    Article  CAS  Google Scholar 

  7. Renard, J.P. et al. Lancet 353, 1489–1491 (1999).

    Article  CAS  Google Scholar 

  8. Wakayama, T. & Yanagimachi, R. Mol. Reprod. Dev. 58, 376–383 (2001).

    Article  CAS  Google Scholar 

  9. Wakayama, T., Rodriguez, I., Perry, A.C.F., Yanagimachi, R. & Mombaerts, P. Proc. Natl Acad. Sci. USA 96, 14984–14989 (1999).

    Article  CAS  Google Scholar 

  10. Eggan, K. et al. Proc. Natl Acad. Sci. USA 98, 6209–6214 (2001).

    Article  CAS  Google Scholar 

  11. Willadsen, S.M. Nature 320, 63–65 (1986).

    Article  CAS  Google Scholar 

  12. Ogura, A., Inoue, K., Takano, K., Wakayama, T. & Yanagimachi, R. Mol. Reprod. Dev. 57, 55–59 (2000).

    Article  CAS  Google Scholar 

  13. Tyner, S.D. et al. Nature 415, 45–53 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Advanced Cell Technology, One Innovation Drive, Worcester, 01605, Massachusetts, USA

    Anthony C.F. Perry & Teruhiko Wakayama

  2. Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku Kobe, 650-0047, Japan

    Teruhiko Wakayama

Authors
  1. Anthony C.F. Perry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Teruhiko Wakayama
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Perry, A., Wakayama, T. Untimely ends and new beginnings in mouse cloning. Nat Genet 30, 243–244 (2002). https://doi.org/10.1038/ng0302-243

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0302-243

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing