Using immunological and cytological approaches, researchers are beginning to reveal the complex molecular components of transcriptionally inert, pericentric heterochromatin. A new study shows that histone modifications and a non-Xist RNA component have essential structural roles in maintaining the tight organization of this type of chromatin.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Neonatal thyroxine activation modifies epigenetic programming of the liver
Nature Communications Open Access 21 July 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Strahl, B.D. & Allis, C.D. Nature 403, 41–45 (2000).
Turner, B.M. Bioessays 22, 836–845 (2000).
Jenuwein, T. & Allis, C.D. Science 293, 1074–1080 (2001).
Zhang, Y. & Reinberg, D. Genes Dev. 15, 2343–2360 (2001).
Lachner, M. & Jenuwein, T. Curr. Opin. Cell Biol. (in the press).
Peters, A.H. et al. Cell 107, 323–337 (2001).
Jacobs, S.A. et al. EMBO J. 20, 5232–5241.
Maison, C. et al. Nature Genet. 30, 329–334 (2002).
Rea, S. et al. Nature 406, 593–599 (2000).
Nakayama, J., Rice, J.C., Strahl, B.D., Allis, C.D. & Grewal, S.I. Science 292, 110–113 (2001).
Aagaard, L. et al. EMBO J. 18, 1923–1938 (1999).
Melcher, M. et al. Mol. Cell. Biol. 20, 3728–3741 (2000).
Akhtar, A., Zink, D., & Becker, P.B. Nature 407, 405–409 (2000).
Boggs, B.A. et al. Nature Genet. 30, 73–76 (2001).
Peters, A.H. et al. Nature Genet. 30, 77–80 (2001).
Heard, E. et al. Cell 107, 727–738 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Briggs, S., Strahl, B. Unraveling heterochromatin. Nat Genet 30, 241–242 (2002). https://doi.org/10.1038/ng0302-241
Issue Date:
DOI: https://doi.org/10.1038/ng0302-241
This article is cited by
-
Neonatal thyroxine activation modifies epigenetic programming of the liver
Nature Communications (2021)