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Co-occurrence of MYC amplification and TP53 mutations in human cancer

Nature Genetics volume 48, pages 104–106 (2016)Cite this article

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To the Editor:

The MYC oncogene is one of the most highly amplified oncogenes in a variety of human cancers1 and belongs to the relatively small number of currently known cancer driver genes2. Mutations in cancer driver genes directly or indirectly cause a selective growth advantage by affecting specific cellular signaling pathways. Correct identification of the molecular components of these pathways is of utmost importance to understanding the underlying biology of malignant diseases and to improving treatment options, and it was designated “one of the greatest achievements of biomedical research” (ref. 2). It has frequently been reported that MYC amplifications affect the cell cycle and apoptosis pathway2.

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Figure 1: Characteristics of MYC amplifications and TP53 mutations in the TCGA data set.

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Acknowledgements

This work was supported by the Austrian Science Fund (FWF) (grants P20338 and P23284), the Oesterreichische Nationalbank (project 15093) and CANCER-ID, a project funded by the Innovative Medicines Joint Undertaking (IMI JU).

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  1. Institute of Human Genetics, Medical University of Graz, Graz, Austria

    Peter Ulz, Ellen Heitzer & Michael R Speicher

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  1. Peter Ulz
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  2. Ellen Heitzer
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  3. Michael R Speicher
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Correspondence to Michael R Speicher.

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The authors declare no competing financial interests.

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Ulz, P., Heitzer, E. & Speicher, M. Co-occurrence of MYC amplification and TP53 mutations in human cancer. Nat Genet 48, 104–106 (2016). https://doi.org/10.1038/ng.3468

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