Transcription of genomic loci containing protein-coding genes often yields not only cognate mRNAs but also assorted noncoding RNAs (ncRNAs), which typically map in the vicinity of transcription start sites. A new study shows that far from being random byproducts of gene expression, many long ncRNAs (lncRNAs) are synthesized in a coordinate fashion and control important cellular processes, such as survival in the face of DNA damage.
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References
Brannan, C.I., Dees, E.C., Ingram, R.S. & Tilghman, S.M. Mol. Cell. Biol. 10, 28–36 (1990).
Pfeifer, K., Leighton, P.A. & Tilghman, S.M. Proc. Natl. Acad. Sci. USA 93, 13876–13883 (1996).
Katayama, S. et al. Science 309, 1564–1566 (2005).
Herzing, L.B., Romer, J.T., Horn, J.M. & Ashworth, A. Nature 386, 272–275 (1997).
Hung, T. et al. Nat. Genet. 43, 621–629 (2011).
Ørom, U.A. & Shiekhattar, R. Curr. Opin. Genet. Dev. 21, 194–198 (2011).
Zhou, Y. et al. J. Biol. Chem. 282, 24731–24742 (2007).
Benetatos, L., Vartholomatos, G. & Hatzimichael, E. Int. J. Cancer published online, doi:10.1002/ijc.26052 (21 March 2011).
Huarte, M. et al. Cell 142, 409–419 (2010).
Morachis, J.M., Murawsky, C.M. & Emerson, B.M. Genes Dev. 24, 135–147 (2010).
Manni, I. et al. Mol. Biol. Cell 19, 5203–5213 (2008).
Ceribelli, M., Alcalay, M., Vigano, M.A. & Mantovani, R. Cell Cycle 5, 1102–1110 (2006).
Benatti, P. et al. Nucleic Acids Res. 36, 1415–1428 (2008).
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The authors are supported by the National Institutes of Health grant CA122334 (A.T.-T.) and Alex's Lemonade Stand Foundation Innovation (A.T.-T.) and Young Investigator (E.S.) awards.
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Sotillo, E., Thomas-Tikhonenko, A. The long reach of noncoding RNAs. Nat Genet 43, 616–617 (2011). https://doi.org/10.1038/ng.870
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DOI: https://doi.org/10.1038/ng.870
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