Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stopping RNA interference at the seed

MicroRNAs (miRNAs) regulate expression of more than one half of the genes in the human genome. A study now reports a new method for selectively silencing whole families of miRNAs, thus providing a new paradigm for disease therapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Silencing miRNA families with tiny LNAs.

References

  1. Lee, R.C., Feinbaum, R.L. & Ambros, V. Cell 75, 843–854 (1993).

    Article  CAS  Google Scholar 

  2. Garzon, R., Marcucci, G. & Croce, C.M. Nat. Rev. Drug Discov. 9, 775–789 (2010).

    Article  CAS  Google Scholar 

  3. Obad, S. et al. Nat. Genet. 43, 371–378 (2011).

    Article  CAS  Google Scholar 

  4. Krützfeldt, J. et al. Nature 438, 685–689 (2005).

    Article  Google Scholar 

  5. Krützfeldt, J. et al. Nucleic Acids Res. 35, 2885–2892 (2007).

    Article  Google Scholar 

  6. Lewis, B.P., Burge, C.B. & Bartel, D.P. Cell 120, 15–20 (2005).

    Article  CAS  Google Scholar 

  7. Baek, D. et al. Nature 455, 64–71 (2008).

    Article  CAS  Google Scholar 

  8. Ebert, M.S., Neilson, J.R. & Sharp, P.A. Nat. Methods 4, 721–726 (2007).

    Article  CAS  Google Scholar 

  9. Orum, H. & Wengel, J. Curr. Opin. Mol. Ther. 3, 239–243 (2001).

    CAS  PubMed  Google Scholar 

  10. Elmén, J. et al. Nature 452, 896–899 (2008).

    Article  Google Scholar 

  11. Meister, G. et al. Mol. Cell 15, 185–197 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John J Rossi.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rossi, J. Stopping RNA interference at the seed. Nat Genet 43, 288–289 (2011). https://doi.org/10.1038/ng0411-288

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0411-288

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing