A new study demonstrates that PRDM9 variation in humans leads to profound differences in the activity of hotspots for both allelic recombination and genomic instability. Although PRDM9 is found to play a role in many more human hotspots than previously suspected, the search remains for additional, undetermined factors involved in defining hotspot locations and intensities.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Ruminant-specific multiple duplication events of PRDM9 before speciation
BMC Evolutionary Biology Open Access 14 March 2017
-
On the origin of crossover interference: A chromosome oscillatory movement (COM) model
Molecular Cytogenetics Open Access 08 April 2011
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ptak, S.E. et al. Nat. Genet. 37, 429–434 (2005).
Winckler, W. et al. Science 308, 107–111 (2005).
Baudat, F. et al. Science 327, 836–840 (2010).
Parvanov, E.D., Petkov, P.M. & Paigen, K. Science 327, 835 (2010).
Myers, S. et al. Science 327, 876–879 (2010).
Berg, I.L. et al. Nat. Genet. 42, 859–863 (2010).
Myers, S., Freeman, C., Auton, A., Donnelly, P. & McVean, G. Nat. Genet. 40, 1124–1129 (2008).
Borde, V. et al. EMBO J. 28, 99–111 (2009).
Buard, J., Barthes, P., Grey, C. & de Massy, B. EMBO J. 28, 2616–2624 (2009).
Lindsay, S.J., Khajavi, M., Lupski, J.R. & Hurles, M.E. Am. J. Hum. Genet. 79, 890–902 (2006).
Myers, S., Bottolo, L., Freeman, C., McVean, G. & Donnelly, P. Science 310, 321–324 (2005).
Kong, A. et al. Science 319, 1398–1401 (2008).
Chowdhury, R., Bois, P.R., Feingold, E., Sherman, S.L. & Cheung, V.G. PLoS Genet. 5, e1000648 (2009).
Broman, K.W., Murray, J.C., Sheffield, V.C., White, R.L. & Weber, J.L. Am. J. Hum. Genet. 63, 861–869 (1998).
Jeffreys, A.J. & Neumann, R. Hum. Mol. Genet. 14, 2277–2287 (2005).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
McVean, G., Myers, S. PRDM9 marks the spot. Nat Genet 42, 821–822 (2010). https://doi.org/10.1038/ng1010-821
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng1010-821
This article is cited by
-
Ruminant-specific multiple duplication events of PRDM9 before speciation
BMC Evolutionary Biology (2017)
-
On the origin of crossover interference: A chromosome oscillatory movement (COM) model
Molecular Cytogenetics (2011)