Filipa Rijo-Ferreira et al. [Artwork by Fernando Augusto]

Sleeping sickness is a circadian disorder

Latest Research

  • Article | | open

    During early postnatal development in mammals, cardiomyocytes exit the cell cycle, losing their regenerative capacity. Here the authors show that, following myocardial infarction, loss of microRNA-128 promotes cardiomyocyte proliferation and cardiac regeneration in adult mice partly via enhancing the expression of the chromatin modifier SUZ12.

    • Wei Huang
    • , Yuliang Feng
    • , Jialiang Liang
    • , Hao Yu
    • , Cheng Wang
    • , Boyu Wang
    • , Mingyang Wang
    • , Lin Jiang
    • , Wei Meng
    • , Wenfeng Cai
    • , Mario Medvedovic
    • , Jenny Chen
    • , Christian Paul
    • , W. Sean Davidson
    • , Sakthivel Sadayappan
    • , Peter J. Stambrook
    • , Xi-Yong Yu
    •  & Yigang Wang
  • Article | | open

    Novel cathode design holds the key to enabling high performance lithium-sulfur batteries. Here the authors utilize anthraquinone to chemically stabilize polysulfides, revealing that the keto groups of anthraquinone play a critical role in forming strong Lewis acid-based chemical bonding.

    • Ge Li
    • , Xiaolei Wang
    • , Min Ho Seo
    • , Matthew Li
    • , Lu Ma
    • , Yifei Yuan
    • , Tianpin Wu
    • , Aiping Yu
    • , Shun Wang
    • , Jun Lu
    •  & Zhongwei Chen
  • Article | | open

    IL-17-producing T cells are protective against infection, but the authors of this article previously showed that these cells also contribute to inflammatory bone destruction. Here they show in the context of periodontitis that microbiota-driven Th17-mediated bone destruction may actually be a physiological rather than a pathological process, as associated tooth loss prevents dissemination of oral bacteria.

    • Masayuki Tsukasaki
    • , Noriko Komatsu
    • , Kazuki Nagashima
    • , Takeshi Nitta
    • , Warunee Pluemsakunthai
    • , Chisa Shukunami
    • , Yoichiro Iwakura
    • , Tomoki Nakashima
    • , Kazuo Okamoto
    •  & Hiroshi Takayanagi
  • Article | | open

    Current methods for prioritization of non-coding genetic risk variants are based on sequence and chromatin features. Here, Gao et al. develop ARVIN, which predicts causal regulatory variants using disease-relevant gene-regulatory networks, and validate this approach in reporter gene assays.

    • Long Gao
    • , Yasin Uzun
    • , Peng Gao
    • , Bing He
    • , Xiaoke Ma
    • , Jiahui Wang
    • , Shizhong Han
    •  & Kai Tan
  • Article | | open

    Gut microbial dysbiosis in infancy is associated with childhood atopy and the development of asthma. Here, the authors show that gut microbiota perturbation is evident in the very earliest stages of postnatal life, continues throughout infancy, and can be partially rescued by Lactobacillus supplementation in high-risk for asthma infants.

    • Juliana Durack
    • , Nikole E. Kimes
    • , Din L. Lin
    • , Marcus Rauch
    • , Michelle McKean
    • , Kathryn McCauley
    • , Ariane R. Panzer
    • , Jordan S. Mar
    • , Michael D. Cabana
    •  & Susan V. Lynch
  • Article | | open

    Obesity can affect bone marrow cell differentiation and the generation of myeloid and lymphoid cells. Here, the authors show that diet and obesity, as well as low-dose lipopolysaccharide, can alter Toll-like receptor 4 signaling bone marrow cells to skew the myeloid-lymphoid homeostasis in mice.

    • Ailing Liu
    • , Minhui Chen
    • , Rashmi Kumar
    • , Maja Stefanovic-Racic
    • , Robert M. O’Doherty
    • , Ying Ding
    • , Willi Jahnen-Dechent
    •  & Lisa Borghesi

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