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  • Article | | open

    Phase modifications take place in electron transport through quantum dots, yet the details are not agreed between theory and experimental observations to date. Edlbauer et al. confirm the theory by scanning fourteen consecutive resonant states of a large quantum dot hosting hundreds of electrons.

    • Hermann Edlbauer
    • , Shintaro Takada
    • , Grégoire Roussely
    • , Michihisa Yamamoto
    • , Seigo Tarucha
    • , Arne Ludwig
    • , Andreas D. Wieck
    • , Tristan Meunier
    •  & Christopher Bäuerle
  • Article | | open

    The magnitude of organic carbon burial in lakes and reservoirs is poorly constrained. Here, using a compilation of modern data from the literature and statistical modeling, the authors estimate a global yearly organic carbon burial of 0.15 Pg C in inland waters, of which 40% is stored in reservoirs.

    • Raquel Mendonça
    • , Roger A. Müller
    • , David Clow
    • , Charles Verpoorter
    • , Peter Raymond
    • , Lars J. Tranvik
    •  & Sebastian Sobek
  • Article | | open

    Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.

    • Mai Thi Nhu Tran
    • , Michito Hamada
    • , Hyojung Jeon
    • , Risako Shiraishi
    • , Keigo Asano
    • , Motochika Hattori
    • , Megumi Nakamura
    • , Yuki Imamura
    • , Yuki Tsunakawa
    • , Risa Fujii
    • , Toshiaki Usui
    • , Kaushalya Kulathunga
    • , Christina-Sylvia Andrea
    • , Ryusuke Koshida
    • , Risa Kamei
    • , Yurina Matsunaga
    • , Makoto Kobayashi
    • , Hisashi Oishi
    • , Takashi Kudo
    •  & Satoru Takahashi
  • Article | | open

    Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a second small molecule binding site, which is of interest for drug design.

    • Ariel Lewis-Ballester
    • , Khoa N. Pham
    • , Dipanwita Batabyal
    • , Shay Karkashon
    • , Jeffrey B. Bonanno
    • , Thomas L. Poulos
    •  & Syun-Ru Yeh
  • Article | | open

    Extracellular vesicles (EV)-associated RNAs are serum biomarkers potentially exploitable for early cancer diagnosis. Here the authors develop a catalyzed hairpin DNA circuit within a cationic lipid-polymer hybrid nanoparticle that can detect low–level EV-associated RNAs in early stage cancer patients.

    • Jiaming Hu
    • , Yan Sheng
    • , Kwang Joo Kwak
    • , Junfeng Shi
    • , Bohao Yu
    •  & L. James Lee
  • Article | | open

    It is unclear whether the transfer of plasmids carrying antibiotic resistance genes can explain their persistence when antibiotics are not present. Here, Lopatkin et al. show that conjugal plasmids, even when costly, are indeed transferred at sufficiently high rates to be maintained in the absence of antibiotics.

    • Allison J. Lopatkin
    • , Hannah R. Meredith
    • , Jaydeep K. Srimani
    • , Connor Pfeiffer
    • , Rick Durrett
    •  & Lingchong You

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