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New ways to nudge splicing

Duplexes formed between pre-mRNA and 2′-fluorinated oligonucleotides suppress nearby splice sites by recruiting double-stranded RNA–binding proteins.

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Figure 1: Expected and unexpected effects of targeted complementary oligonucleotides on splicing.

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Correspondence to Ian Eperon.

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The author declares no competing financial interests.

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Eperon, I. New ways to nudge splicing. Nat Chem Biol 8, 507–508 (2012). https://doi.org/10.1038/nchembio.968

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