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Infectious diseases

Transporter targeted in tuberculosis

Nature Chemical Biology volume 8, pages 326–327 (2012)Cite this article

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The cell wall of tubercle bacilli is targeted by many drugs. A new adamantyl urea compound unveils MmpL3, a member of the resistance, nodulation and division protein family, as the long-sought trehalose monomycolate transporter, essential for translocation of mycolic acids into the cell envelope.

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Figure 1: Schematic showing a simplified view of the mycobacterial cell envelope and location of the MmpL3 transporter for TMM.

References

  1. Barry, C.E., Crick, D.C. & McNeil, M.R. Infect. Disord. Drug Targets 7, 182–202 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Grzegorzewicz, A.E. et al. Nat. Chem. Biol. 8, 334–341 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Saier, M.H. Jr. & Paulsen, I.T. Semin. Cell Dev. Biol. 12, 205–213 (2001).

    Article  CAS  PubMed  Google Scholar 

  4. Tekaia, F. et al. Tuber. Lung Dis. 79, 329–342 (1999).

    Article  CAS  PubMed  Google Scholar 

  5. Murakami, S., Nakashima, R., Yamashita, E. & Yamaguchi, A. Nature 419, 587–593 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Jain, M., Chow, E.D. & Cox, J.S. in The Mycobacterial Cell Envelope (eds. Daffé, M. & Reyrat J.-M.) 201–210 (ASM Press, 2008).

    Book  Google Scholar 

  7. Domenech, P., Reed, M.B. & Barry, C.E. III. Infect. Immun. 73, 3492–3501 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Tahlan, K. et al. Antimicrob. Agents Chemother. advance online publication, 10.1128/AAC.05708-11 (17 January 2012).

  9. La Rosa, V. et al. Antimicrob. Agents Chemother. 56, 324–331 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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  1. Stewart T. Cole is at the Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.,

    Stewart T Cole

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  1. Stewart T Cole
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Correspondence to Stewart T Cole.

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The author declares no competing financial interests.

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Cole, S. Transporter targeted in tuberculosis. Nat Chem Biol 8, 326–327 (2012). https://doi.org/10.1038/nchembio.918

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