Classical cannabinoid receptors do not mediate all actions of the active drug in cannabis, THC. Here the mechanism by which THC enhances glycine receptor activity has been identified and used to design new pain therapeutics that avoid THC's adverse effects.
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Christie, M., Vaughan, C. Cannabis medicine without a high. Nat Chem Biol 7, 249–250 (2011). https://doi.org/10.1038/nchembio.567
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DOI: https://doi.org/10.1038/nchembio.567