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Antibiotics

Vancomycin sensing

Nature Chemical Biology volume 6, pages 313–315 (2010)Cite this article

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Bacteria resistant to glycopeptides such as vancomycin sense the drugs and escape killing by remodeling synthesis of the cell wall target. A photoaffinity probe shows that induction of resistance relies on direct drug recognition by a glycopeptide sensor.

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Figure 1: Modes of action of vancomycin as an inducer of glycopeptide resistance genes and as an inhibitor of peptidoglycan polymerization.

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Author notes

  1. Université Paris Descartes, UMR S 872, Paris, France.

Authors and Affiliations

  1. Michel Arthur is at the Centre de Recherche des Cordeliers, Laboratoire de Recherche Moléculaire sur les Antibiotiques, Equipe 12, INSERM, U872, Paris,

    Michel Arthur

  2. Université Pierre et Marie Curie, Paris, UMR S 872

    Michel Arthur & Michel Arthur

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  1. Michel Arthur
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The author declares no competing financial interests.

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Arthur, M. Vancomycin sensing. Nat Chem Biol 6, 313–315 (2010). https://doi.org/10.1038/nchembio.356

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