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Protein degradation

Prime time for PROTACs

Nature Chemical Biology volume 11, pages 634–635 (2015)Cite this article

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A Corrigendum to this article was published on 20 October 2015

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PROTACs are heterobifunctional small molecules that simultaneously bind a target protein and a ubiquitin ligase, enabling ubiquitination and degradation of the target. Major progress in developing potent and specific PROTACs has recently been reported, invigorating prospects for novel PROTAC-based therapies.

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Figure 1: PROTAC mechanism of action and modular structure.

Katie Vicari/Nature Publishing Group

Change history

  • 23 September 2015

    In the version of this article originally published, the protein ERRα was mislabeled as BRD4 in Figure 1 and its legend, and the citation of the figure in the text was misplaced. These errors have been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Raymond J. Deshaies is in the Howard Hughes Medical Institute and Division of Biology and Biological Engineering, Caltech, Pasadena, California, USA.,

    Raymond J Deshaies

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  1. Raymond J Deshaies
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Correspondence to Raymond J Deshaies.

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Competing interests

R.J.D. is co-founder of a company (Cleave Biosciences) that is developing therapeutics based on targeting enzymes in the ubiquitin-proteasome pathway. R.J.D. also holds stock in Cleave Biosciences and serves as a consultant and member of their Scientific Advisory Board.

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Deshaies, R. Prime time for PROTACs. Nat Chem Biol 11, 634–635 (2015). https://doi.org/10.1038/nchembio.1887

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