A synthetic strategy that uses a series of simple reactions to distort the core architecture of complex natural products could provide libraries of stereochemically rich compounds that will help in the search for new biological probes and drugs.
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References
Dixon, N., Wong, L. S., Geerlings, T. H. & Micklefield, J. Nat. Prod. Rep. 24, 1288–1310 (2007).
Carlson, E. E. ACS Chem. Biol. 5, 639–653 (2010).
Newman, D. J. & Cragg, G. M. J. Nat. Prod. 75, 311–335 (2012).
Scannell, J. W., Blanckley, A., Boldon, H. & Warrington, B. Nature Rev. Drug Discov. 11, 191–200 (2012).
Pommier, Y. & Marchand, C. Nature Rev. Drug Discov. 11, 25–36 (2012).
Burke, M. D. & Schreiber, S. L. Angew. Chem. Int. Ed. 43, 46–58 (2004).
Wetzel, S., Bon, R. S., Kumar, K. & Waldmann, H. Angew. Chem. Int. Ed. 50, 10800–10826 (2011).
Welsch, M. E., Snyder, S. A. & Stockwell, B. R. Curr. Opin. Chem. Biol. 14, 347–361 (2010).
Bauer, R. A., Wurst, J. M. & Tan, D. S. Curr. Opin. Chem. Biol. 14, 308–314 (2010).
Hert, J., Irwin, J. J., Laggner, C., Keiser, M. J. & Shoichet, B. K. Nature Chem. Biol. 5, 479–483 (2009).
Clemons, P. A. et al. Proc. Natl Acad. Sci. USA 107, 18787–18792 (2010).
Lovering, F., Bikker, J. & Humblet, C. J. Med. Chem. 52, 6752–6756 (2009).
Ritchie, T. J. & MacDonald, S. J. F. Drug Discov. Today 14, 1011–1020 (2009).
Luker, T. et al. Bioorg. Med. Chem. Lett. 21, 5673–5679 (2011).
Huigens, R. W. III et al. Nature Chem. 5, 195–202 (2013).10.1038/nchem.1549
Nielsen, T. E. & Schreiber, S. L. Angew. Chem. Int. Ed. 47, 48–56 (2008).
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Sharma, I., Tan, D. Diversifying complexity. Nature Chem 5, 157–158 (2013). https://doi.org/10.1038/nchem.1581
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DOI: https://doi.org/10.1038/nchem.1581