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cover image Fluorescence photograph of paxillin (red) and actin (green) in kidney epithelial cells. Nuclei are shown in blue. [Cover design: Majo Xeridat] [review, pE231]
Scientific images should not be seen as by-products of scientific research but as art in their own right. As science funding bodies are now coming to realize, exhibiting this artwork can also serve to highlight the science that created it
ATM, the product of the gene that is mutated in the human genetic disorder ataxia telangiectasia (A-T), responds to DNA damage by phosphorylating several key substrates that are involved in both the sensing of damage and the activation of cell-cycle checkpoints. The unexpected activation of ATM kinase in response to insulin supports a more general signalling role for this enzyme.
Recent studies have shown that under conditions of Golgi breakdown, Golgi glycosylation enzymes recycle to the endoplasmic reticulum (ER), whereas Golgi matrix proteins are retained in a set of cytoplasmic membranes. These findings have implications for the role of the ER in Golgi reassembly.
