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The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants

Nature Cell Biology volume 2, pages 948–952 (2000)Cite this article

Abstract

Here we show that the rate of poleward chromosome motion in zw10-null mutants is greatly attenuated throughout the division process, and that chromosome disjunction at anaphase is highly asynchronous. Our results show that ZW10 protein, together with Rod, is involved in production and/or regulation of the force reponsible for poleward chromosome motion.

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Figure 1: Meiosis I in a wild-type Drosophila spermatocyte.
Figure 2: Anaphase I in a zw10-null spermatocyte in which two of the four bivalents lie in the same focal plane.
Figure 3: Anaphase I in a spermatocyte mutant for Rod.
Figure 4: Behaviour of sister kinetochore regions after severing a bi-orientated bivalent.

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Acknowledgements

We thank B. C. Williams, R. Cole, H. Chotowski, R. Glaser and A. Khodjakov for assistance. This work was supported by NIH GMS grants 40198 (to C.L.R.) and 48430 (to M.L.G.).

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Authors and Affiliations

  1. Division of Molecular Medicine, New York State Department of Health, Wadsworth Center, Albany, 12201-0509, New York, USA

    Matthew S. Savoian & Conly L. Rieder

  2. Department of Biomedical Sciences, State University of New York, Albany, 12222, New York, USA

    Matthew S. Savoian & Conly L. Rieder

  3. Department of Molecular Biology and Genetics, Cornell University, Ithaca, 14853, New York, USA

    Michael L. Goldberg

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  1. Matthew S. Savoian
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Correspondence to Conly L. Rieder.

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Savoian, M., Goldberg, M. & Rieder, C. The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants. Nat Cell Biol 2, 948–952 (2000). https://doi.org/10.1038/35046605

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