Milestones in gene expression - p1149

doi:10.1038/ncb1205-1149a

Full Text - Milestones in gene expression | PDF (133 KB) - Milestones in gene expression

Intelligent debate - p1149

doi:10.1038/ncb1205-1149b

Full Text - Intelligent debate | PDF (133 KB) - Intelligent debate

The secular religion of evolution(ism) - p1150

John M. Lynch reviews The Evolution–Creation Struggle by Michael Ruse

doi:10.1038/ncb1205-1150

Full Text - The secular religion of evolution(ism) | PDF (146 KB) - The secular religion of evolution(ism)

The ins and outs of endocytic transport - pp1151 - 1154

Barth D. Grant & Anjon Audhya

doi:10.1038/ncb1205-1151

A fusion of cutting-edge research in cell biology, developmental biology and immunology made the recent workshop on Membrane Dynamics in Endocytosis an outstanding success. Members of an increasingly diverse community converged upon the small town of Sant Feliu de Guixols on the coast of Spain, between September 17–22, 2005, to discuss common themes emerging from their studies on membrane transport. Organized by Margaret Robinson (Cambridge, UK) and Howard Riezman (Geneva, Switzerland), the meeting covered diverse topics that highlighted essential roles for endocytosis during cell growth, development and parasitic invasion.

Full Text - The ins and outs of endocytic transport | PDF (215 KB) - The ins and outs of endocytic transport

Moving with Muscleblind - pp1155 - 1156

Goncalo Rebelo de Andrade & Ralf-Peter Jansen

doi:10.1038/ncb1205-1155

In myotonic dystrophy, a group of RNA-binding factors — the Muscleblind-like proteins — are sequestered by transcripts containing expanded trinucleotide repeats; this sequestration disrupts their proposed physiological function as regulators of alternative splicing. Now, exciting data suggest that Muscleblind-like proteins are also involved in the localization of integrin mRNA.

Full Text - Moving with Muscleblind | PDF (220 KB) - Moving with Muscleblind

See also: Letter by Adereth et al.

Pins for spines - pp1157 - 1158

Juergen A. Knoblich

doi:10.1038/ncb1205-1157

Neurotransmitter receptors must be targeted to the post-synaptic membrane to perform their function in synaptic transmission. Recent findings reveal a surprising role for heterotrimeric G proteins and their activator, Pins (Partner of Inscuteable), in this important protein targeting event.

Full Text - Pins for spines | PDF (225 KB) - Pins for spines

See also: Article by Sans et al.

Receptor regulation: -arrestin moves up a notch - pp1159 - 1161

Sudha K. Shenoy & Robert J. Lefkowitz

doi:10.1038/ncb1205-1159

-arrestin, a protein known to regulate the signalling, trafficking and degradation of mammalian seven-transmembrane-spanning receptors, has now been identified as a regulator of ubiquitination and degradation of the Notch receptor in Drosophila melanogaster.

Full Text - Receptor regulation: -arrestin moves up a notch | PDF (257 KB) - Receptor regulation: -arrestin moves up a notch

See also: Article by Mukherjee et al.

Apoptosis: eating sensibly - pp1161 - 1163

Christopher D. Gregory & Simon B. Brown

doi:10.1038/ncb1205-1161

Phagocytes may engulf both apoptotic and viable cells via calreticulin on the surface of the target cell, through its interaction with the phagocyte receptor, LRP. In reality, however, only apoptotic cells are engulfed, apparently because their surface ligand CD47 is prevented from activating the inhibitory phagocyte receptor SIRP.

Full Text - Apoptosis: eating sensibly | PDF (255 KB) - Apoptosis: eating sensibly

Polycystins: inhibiting the inhibitors - pp1164 - 1165

Robert Benezra

doi:10.1038/ncb1205-1164

Polycystin-1 and -2 — two integral membrane proteins that are mutated in polycystic kidney disease — regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein Id2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders.

Full Text - Polycystins: inhibiting the inhibitors | PDF (215 KB) - Polycystins: inhibiting the inhibitors

See also: Article by Li et al.

Cadherins reach out - p1166

Alison Schuldt

doi:10.1038/ncb1205-1166

Full Text - Cadherins reach out | PDF (281 KB) - Cadherins reach out

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development - pp1167 - 1178

Atsushi Kamiya, Ken-ichiro Kubo, Toshifumi Tomoda, Manabu Takaki, Richard Youn, Yuji Ozeki, Naoya Sawamura, Una Park, Chikako Kudo, Masako Okawa, Christopher A. Ross, Mary E. Hatten, Kazunori Nakajima & Akira Sawa

doi:10.1038/ncb1328

Abstract - | Full Text - A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development | PDF (2,367 KB) - A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development | Supplementary information

mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression - pp1179 - 1190

Nathalie Sans, Philip Y. Wang, Quansheng Du, Ronald S. Petralia, Ya-Xian Wang, Sajan Nakka, Joe B. Blumer, Ian G. Macara & Robert J. Wenthold

doi:10.1038/ncb1325

Abstract - | Full Text - mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression | PDF (2,761 KB) - mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression | Supplementary information

See also: News and Views by Knoblich

Regulation of Notch signalling by non-visual -arrestin - pp1191 - 1201

Ashim Mukherjee, Alexey Veraksa, Andreas Bauer, Carine Rosse, Jacques Camonis & Spyros Artavanis-Tsakonas

doi:10.1038/ncb1327

Abstract - | Full Text - Regulation of Notch signalling by non-visual -arrestin | PDF (2,512 KB) - Regulation of Notch signalling by non-visual -arrestin | Supplementary information

See also: News and Views by Shenoy & Lefkowitz

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix–loop–helix inhibitor Id2 - pp1202 - 1212

Xiaogang Li, Ying Luo, Patrick G. Starremans, Coleen A. McNamara, York Pei & Jing Zhou

doi:10.1038/ncb1326

Abstract - | Full Text - Polycystin-1 and polycystin-2 regulate the cell cycle through the helix–loop–helix inhibitor Id2 | PDF (1,146 KB) - Polycystin-1 and polycystin-2 regulate the cell cycle through the helix–loop–helix inhibitor Id2 | Supplementary information

See also: News and Views by Benezra

Centering of a radial microtubule array by translocation along microtubules spontaneously nucleated in the cytoplasm - pp1213 - 1218

Viacheslav Malikov, Eric N. Cytrynbaum, Anna Kashina, Alexander Mogilner & Vladimir Rodionov

doi:10.1038/ncb1332

First Paragraph - | Full Text - Centering of a radial microtubule array by translocation along microtubules spontaneously nucleated in the cytoplasm | PDF (2,089 KB) - Centering of a radial microtubule array by translocation along microtubules spontaneously nucleated in the cytoplasm | Supplementary information

Loading history determines the velocity of actin-network growth - pp1219 - 1223

Sapun H. Parekh, Ovijit Chaudhuri, Julie A. Theriot & Daniel A. Fletcher

doi:10.1038/ncb1336

First Paragraph - | Full Text - Loading history determines the velocity of actin-network growth | PDF (1,075 KB) - Loading history determines the velocity of actin-network growth | Supplementary information

Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast - pp1224 - 1231

Arsenio Villarejo, Stefan Burén, Susanne Larsson, Annabelle Déjardin, Magnus Monné, Charlotta Rudhe, Jan Karlsson, Stefan Jansson, Patrice Lerouge, Norbert Rolland, Gunnar von Heijne, Markus Grebe, Laszlo Bako & Göran Samuelsson

doi:10.1038/ncb1330

First Paragraph - | Full Text - Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast | PDF (3,583 KB) - Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast | Supplementary information

Endocytic control of epithelial polarity and proliferation in Drosophila - pp1232 - 1239

Han Lu & David Bilder

doi:10.1038/ncb1324

First Paragraph - | Full Text - Endocytic control of epithelial polarity and proliferation in Drosophila | PDF (2,547 KB) - Endocytic control of epithelial polarity and proliferation in Drosophila | Supplementary information

RNA-dependent integrin ₃ protein localization regulated by the Muscleblind-like protein MLP1 - pp1240 - 1247

Yair Adereth, Vincent Dammai, Nurgun Kose, Runzhao Li & Tien Hsu

doi:10.1038/ncb1335

First Paragraph - | Full Text - RNA-dependent integrin 3 protein localization regulated by the Muscleblind-like protein MLP1 | PDF (1,418 KB) - RNA-dependent integrin 3 protein localization regulated by the Muscleblind-like protein MLP1 | Supplementary information

See also: News and Views by de Andrade & Jansen

Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis - pp1248 - 1255

Joost Monen, Paul S. Maddox, Francie Hyndman, Karen Oegema & Arshad Desai

doi:10.1038/ncb1331

First Paragraph - | Full Text - Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis | PDF (1,410 KB) - Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis | Supplementary information

Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36 - pp1256 - 1260

Zhong Zhao, Yu Yu, Denise Meyer, Chengjun Wu & Wen-Hui Shen

doi:10.1038/ncb1329

First Paragraph - | Full Text - Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36 | PDF (1,051 KB) - Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36 | Supplementary information

A role for the P-body component GW182 in microRNA function - pp1261 - 1266

Jidong Liu, Fabiola V. Rivas, James Wohlschlegel, John R. Yates, III, Roy Parker & Gregory J. Hannon

doi:10.1038/ncb1333

First Paragraph - | Full Text - A role for the P-body component GW182 in microRNA function | PDF (952 KB) - A role for the P-body component GW182 in microRNA function | Supplementary information

Disruption of GW bodies impairs mammalian RNA interference - pp1267 - 1274

Andrew Jakymiw, Shangli Lian, Theophany Eystathioy, Songqing Li, Minoru Satoh, John C. Hamel, Marvin J. Fritzler & Edward K.L. Chan

doi:10.1038/ncb1334

First Paragraph - | Full Text - Disruption of GW bodies impairs mammalian RNA interference | PDF (1,709 KB) - Disruption of GW bodies impairs mammalian RNA interference | Supplementary information