Table of contents


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Editorials

Milestones in gene expression p1149

doi:10.1038/ncb1205-1149a


Intelligent debate p1149

doi:10.1038/ncb1205-1149b


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Book Review

The secular religion of evolution(ism) p1150

John M. Lynch reviews The Evolution–Creation Struggle by Michael Ruse

doi:10.1038/ncb1205-1150


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Meeting Report

The ins and outs of endocytic transport pp1151 - 1154

Barth D. Grant & Anjon Audhya

doi:10.1038/ncb1205-1151

A fusion of cutting-edge research in cell biology, developmental biology and immunology made the recent workshop on Membrane Dynamics in Endocytosis an outstanding success. Members of an increasingly diverse community converged upon the small town of Sant Feliu de Guixols on the coast of Spain, between September 17–22, 2005, to discuss common themes emerging from their studies on membrane transport. Organized by Margaret Robinson (Cambridge, UK) and Howard Riezman (Geneva, Switzerland), the meeting covered diverse topics that highlighted essential roles for endocytosis during cell growth, development and parasitic invasion.


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News and Views

Moving with Muscleblind pp1155 - 1156

Goncalo Rebelo de Andrade & Ralf-Peter Jansen

doi:10.1038/ncb1205-1155

In myotonic dystrophy, a group of RNA-binding factors — the Muscleblind-like proteins — are sequestered by transcripts containing expanded trinucleotide repeats; this sequestration disrupts their proposed physiological function as regulators of alternative splicing. Now, exciting data suggest that Muscleblind-like proteins are also involved in the localization of integrin mRNA.

See also: Letter by Adereth et al.


Pins for spines pp1157 - 1158

Juergen A. Knoblich

doi:10.1038/ncb1205-1157

Neurotransmitter receptors must be targeted to the post-synaptic membrane to perform their function in synaptic transmission. Recent findings reveal a surprising role for heterotrimeric G proteins and their activator, Pins (Partner of Inscuteable), in this important protein targeting event.

See also: Article by Sans et al.


Receptor regulation: beta-arrestin moves up a notch pp1159 - 1161

Sudha K. Shenoy & Robert J. Lefkowitz

doi:10.1038/ncb1205-1159

beta-arrestin, a protein known to regulate the signalling, trafficking and degradation of mammalian seven-transmembrane-spanning receptors, has now been identified as a regulator of ubiquitination and degradation of the Notch receptor in Drosophila melanogaster.

See also: Article by Mukherjee et al.


Apoptosis: eating sensibly pp1161 - 1163

Christopher D. Gregory & Simon B. Brown

doi:10.1038/ncb1205-1161

Phagocytes may engulf both apoptotic and viable cells via calreticulin on the surface of the target cell, through its interaction with the phagocyte receptor, LRP. In reality, however, only apoptotic cells are engulfed, apparently because their surface ligand CD47 is prevented from activating the inhibitory phagocyte receptor SIRPalpha.


Polycystins: inhibiting the inhibitors pp1164 - 1165

Robert Benezra

doi:10.1038/ncb1205-1164

Polycystin-1 and -2 — two integral membrane proteins that are mutated in polycystic kidney disease — regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein Id2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders.

See also: Article by Li et al.


Cadherins reach out p1166

Alison Schuldt

doi:10.1038/ncb1205-1166


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Articles

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development pp1167 - 1178

Atsushi Kamiya, Ken-ichiro Kubo, Toshifumi Tomoda, Manabu Takaki, Richard Youn, Yuji Ozeki, Naoya Sawamura, Una Park, Chikako Kudo, Masako Okawa, Christopher A. Ross, Mary E. Hatten, Kazunori Nakajima & Akira Sawa

doi:10.1038/ncb1328


mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression pp1179 - 1190

Nathalie Sans, Philip Y. Wang, Quansheng Du, Ronald S. Petralia, Ya-Xian Wang, Sajan Nakka, Joe B. Blumer, Ian G. Macara & Robert J. Wenthold

doi:10.1038/ncb1325

See also: News and Views by Knoblich


Regulation of Notch signalling by non-visual beta-arrestin pp1191 - 1201

Ashim Mukherjee, Alexey Veraksa, Andreas Bauer, Carine Rosse, Jacques Camonis & Spyros Artavanis-Tsakonas

doi:10.1038/ncb1327

See also: News and Views by Shenoy & Lefkowitz


Polycystin-1 and polycystin-2 regulate the cell cycle through the helix–loop–helix inhibitor Id2 pp1202 - 1212

Xiaogang Li, Ying Luo, Patrick G. Starremans, Coleen A. McNamara, York Pei & Jing Zhou

doi:10.1038/ncb1326

See also: News and Views by Benezra


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Letters

Centering of a radial microtubule array by translocation along microtubules spontaneously nucleated in the cytoplasm pp1213 - 1218

Viacheslav Malikov, Eric N. Cytrynbaum, Anna Kashina, Alexander Mogilner & Vladimir Rodionov

doi:10.1038/ncb1332


Loading history determines the velocity of actin-network growth pp1219 - 1223

Sapun H. Parekh, Ovijit Chaudhuri, Julie A. Theriot & Daniel A. Fletcher

doi:10.1038/ncb1336


Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast pp1224 - 1231

Arsenio Villarejo, Stefan Burén, Susanne Larsson, Annabelle Déjardin, Magnus Monné, Charlotta Rudhe, Jan Karlsson, Stefan Jansson, Patrice Lerouge, Norbert Rolland, Gunnar von Heijne, Markus Grebe, Laszlo Bako & Göran Samuelsson

doi:10.1038/ncb1330



RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1 pp1240 - 1247

Yair Adereth, Vincent Dammai, Nurgun Kose, Runzhao Li & Tien Hsu

doi:10.1038/ncb1335

See also: News and Views by de Andrade & Jansen


Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis pp1248 - 1255

Joost Monen, Paul S. Maddox, Francie Hyndman, Karen Oegema & Arshad Desai

doi:10.1038/ncb1331


Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36 pp1256 - 1260

Zhong Zhao, Yu Yu, Denise Meyer, Chengjun Wu & Wen-Hui Shen

doi:10.1038/ncb1329


A role for the P-body component GW182 in microRNA function pp1261 - 1266

Jidong Liu, Fabiola V. Rivas, James Wohlschlegel, John R. Yates, III, Roy Parker & Gregory J. Hannon

doi:10.1038/ncb1333


Disruption of GW bodies impairs mammalian RNA interference pp1267 - 1274

Andrew Jakymiw, Shangli Lian, Theophany Eystathioy, Songqing Li, Minoru Satoh, John C. Hamel, Marvin J. Fritzler & Edward K.L. Chan

doi:10.1038/ncb1334


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