Table of contents


This month, a special Nature Cell Biology issue on signalling and adhesion casts a spotlight on this dynamic and evolving area of cell biology with a series of specially commissioned Reviews, Perspectives, Commentaries and News & Views articles.

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Editorial

Focus on signalling and adhesion

Signalling and adhesion take centre stage pE63

doi:10.1038/ncb0402-e63


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Commentary

Focus on signalling and adhesion

Networks and crosstalk: integrin signalling spreads ppE65 - E68

Martin A. Schwartz & Mark H. Ginsberg

doi:10.1038/ncb0402-e65

Multicellular organisms must coordinate signals from adhesion receptors with those from other signalling receptors (for example, growth factor receptors). Here, we briefly review paradigms of integrin–adhesion-receptor signalling. We discuss how adhesive signalling is coordinately regulated through intersecting networks. We also examine some examples of how some forms of integrin crosstalk may lead to unforeseen and potentially deleterious responses.


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News and Views

Focus on signalling and adhesion

Herpesvirus hijacks an integrin ppE69 - E71

Glen R. Nemerow & David A. Cheresh

doi:10.1038/ncb0402-e69

Human herpesvirus 8 (HHV-8), an agent associated with Kaposi's sarcoma, binds to integrin alpha3beta1 through its gB envelope glycoprotein, and thus gains entry into human fibroblasts. Based on an analogy with other microbial pathogens, integrin interaction with HHV-8 may induce signalling events that promote cell entry and perhaps facilitate disease progression.


Focus on signalling and adhesion

Neighbourhood Watch for the cytoskeleton pE71

Alison Schuldt

doi:10.1038/ncb0402-e71

See also: Article by Krendel et al.


Focus on signalling and adhesion

E-cadherin and Hakai: signalling, remodeling or destruction? ppE72 - E74

Salvatore Pece & J. Silvio Gutkind

doi:10.1038/ncb0402-e72

Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell–cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial–mesenchymal transitions under physiological and pathological conditions.


Focus on signalling and adhesion

Ready and Abl pE74

Sarah Greaves

doi:10.1038/ncb0402-e74


Focus on signalling and adhesion

Integrin regulation of growth factor receptors ppE75 - E76

Kenneth M. Yamada & Sharona Even-Ram

doi:10.1038/ncb0402-e75

Integrins are receptors for extracellular matrix proteins that engage in reciprocal crosstalk with growth factor receptors. Recent work identifies a unique mechanism for the regulation of growth factor receptor phosphorylation by integrins, indicating multiple ways of achieving cooperation between these major signalling systems.


How Rab proteins link motors to membranes ppE77 - E78

Bruno Goud

doi:10.1038/ncb0402-e77

Small GTPases of the Rab family are essential for the control of membrane transport between intracellular compartments. Recent work has shown that on melanosome membranes, Rab27a initiates the formation of a receptor complex that allows the recruitment of the actin-based motor myosin Va. This study provides a molecular basis for several pathologies that result in pigmentation defects in both mouse and humans.

See also: Article by Wu et al.


Focus on signalling and adhesion

A double-edged sword pE79

Valerie Ferrier

doi:10.1038/ncb0402-e79


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Book Review

Focus on signalling and adhesion

In search of sticky protocols pE80

Frans Van Roy reviews Cell–Cell Interactions by Tom Fleming & Spencer Muse

doi:10.1038/ncb0402-e80


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Web Review

Signalling across the Internet pE82

doi:10.1038/ncb0402-e82


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Historical Perspective

Focus on signalling and adhesion

Sensing the environment: a historical perspective on integrin signal transduction ppE83 - E90

Cindy K. Miranti & Joan S. Brugge

doi:10.1038/ncb0402-e83


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Technology Review

Focus on signalling and adhesion

Microscope-based techniques to study cell adhesion and migration ppE91 - E96

Partha Roy, Zenon Rajfur, Pawel Pomorski & Ken Jacobson

doi:10.1038/ncb0402-e91


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Reviews

Focus on signalling and adhesion

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again ppE97 - E100

Donna J. Webb, J. Thomas Parsons & Alan F. Horwitz

doi:10.1038/ncb0402-e97


Focus on signalling and adhesion

Intercellular adhesion, signalling and the cytoskeleton ppE101 - E108

Colin Jamora & Elaine Fuchs

doi:10.1038/ncb0402-e101


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Articles

Identification of an organelle receptor for myosin-Va pp271 - 278

Xufeng S. Wu, Kang Rao, Hong Zhang, Fei Wang, James R. Sellers, Lydia E. Matesic, Neal G. Copeland, Nancy A. Jenkins & John A. Hammer, III

doi:10.1038/ncb760

See also: News and Views by Goud


Quantal release of free radicals during exocytosis of phagosomes pp279 - 285

Anke Di, Boris Krupa, Vytas P. Bindokas, Yimei Chen, Mary E. Brown, H. Clive Palfrey, Anjaparavanda P. Naren, Kevin L. Kirk & Deborah J. Nelson

doi:10.1038/ncb771


Focus on signalling and adhesion

Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins pp286 - 293

Zenon Rajfur, Partha Roy, Carol Otey, Lewis Romer & Ken Jacobson

doi:10.1038/ncb772


Focus on signalling and adhesion

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton pp294 - 301

Mira Krendel, Frank T. Zenke & Gary M. Bokoch

doi:10.1038/ncb773

See also: News and Views by Schuldt


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Brief Communications

Myosin IXb is a single-headed minus-end-directed processive motor pp302 - 306

Akira Inoue, Junya Saito, Reiko Ikebe & Mitsuo Ikebe

doi:10.1038/ncb774


Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide pp307 - 311

Ulrike Zabel, Christoph Kleinschnitz, Phil Oh, Pavel Nedvetsky, Albert Smolenski, Helmut Müller, Petra Kronich, Peter Kugler, Ulrich Walter, Jan E. Schnitzer & Harald H. H. W. Schmidt

doi:10.1038/ncb775


The myosin converter domain modulates muscle performance pp312 - 317

Douglas M. Swank, Aileen F. Knowles, Jennifer A. Suggs, Floyd Sarsoza, Annie Lee, David W. Maughan & Sanford I. Bernstein

doi:10.1038/ncb776


Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation pp318 - 322

Niels Mailand, Claudia Lukas, Brett K. Kaiser, Peter K. Jackson, Jiri Bartek & Jiri Lukas

doi:10.1038/ncb777


Focus on signalling and adhesion

Identification of a link between the tumour suppressor APC and the kinesin superfamily pp323 - 327

Takeshi Jimbo, Yoshihiro Kawasaki, Ryo Koyama, Rina Sato, Shinji Takada, Keiko Haraguchi & Tetsu Akiyama

doi:10.1038/ncb779


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Errata

erratum p328

doi:10.1038/ncb765


erratum p328

doi:10.1038/ncb769



erratum p328

doi:10.1038/ncb780


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