Focus on signalling and adhesion

Signalling and adhesion take centre stage - pE63

doi:10.1038/ncb0402-e63

Full Text - Signalling and adhesion take centre stage | PDF (60 KB) - Signalling and adhesion take centre stage

Focus on signalling and adhesion

Networks and crosstalk: integrin signalling spreads - ppE65 - E68

Martin A. Schwartz & Mark H. Ginsberg

doi:10.1038/ncb0402-e65

Multicellular organisms must coordinate signals from adhesion receptors with those from other signalling receptors (for example, growth factor receptors). Here, we briefly review paradigms of integrin–adhesion-receptor signalling. We discuss how adhesive signalling is coordinately regulated through intersecting networks. We also examine some examples of how some forms of integrin crosstalk may lead to unforeseen and potentially deleterious responses.

Full Text - Networks and crosstalk: integrin signalling spreads | PDF (94 KB) - Networks and crosstalk: integrin signalling spreads

Focus on signalling and adhesion

Herpesvirus hijacks an integrin - ppE69 - E71

Glen R. Nemerow & David A. Cheresh

doi:10.1038/ncb0402-e69

Human herpesvirus 8 (HHV-8), an agent associated with Kaposi's sarcoma, binds to integrin ₃₁ through its gB envelope glycoprotein, and thus gains entry into human fibroblasts. Based on an analogy with other microbial pathogens, integrin interaction with HHV-8 may induce signalling events that promote cell entry and perhaps facilitate disease progression.

Full Text - Herpesvirus hijacks an integrin | PDF (163 KB) - Herpesvirus hijacks an integrin

Focus on signalling and adhesion

Neighbourhood Watch for the cytoskeleton - pE71

Alison Schuldt

doi:10.1038/ncb0402-e71

Full Text - Neighbourhood Watch for the cytoskeleton | PDF (104 KB) - Neighbourhood Watch for the cytoskeleton

See also: Article by Krendel et al.

Focus on signalling and adhesion

E-cadherin and Hakai: signalling, remodeling or destruction? - ppE72 - E74

Salvatore Pece & J. Silvio Gutkind

doi:10.1038/ncb0402-e72

Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell–cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial–mesenchymal transitions under physiological and pathological conditions.

Full Text - E-cadherin and Hakai: signalling, remodeling or destruction? | PDF (404 KB) - E-cadherin and Hakai: signalling, remodeling or destruction?

Focus on signalling and adhesion

Ready and Abl - pE74

Sarah Greaves

doi:10.1038/ncb0402-e74

Full Text - Ready and Abl | PDF (239 KB) - Ready and Abl

Focus on signalling and adhesion

Integrin regulation of growth factor receptors - ppE75 - E76

Kenneth M. Yamada & Sharona Even-Ram

doi:10.1038/ncb0402-e75

Integrins are receptors for extracellular matrix proteins that engage in reciprocal crosstalk with growth factor receptors. Recent work identifies a unique mechanism for the regulation of growth factor receptor phosphorylation by integrins, indicating multiple ways of achieving cooperation between these major signalling systems.

Full Text - Integrin regulation of growth factor receptors | PDF (124 KB) - Integrin regulation of growth factor receptors

How Rab proteins link motors to membranes - ppE77 - E78

Bruno Goud

doi:10.1038/ncb0402-e77

Small GTPases of the Rab family are essential for the control of membrane transport between intracellular compartments. Recent work has shown that on melanosome membranes, Rab27a initiates the formation of a receptor complex that allows the recruitment of the actin-based motor myosin Va. This study provides a molecular basis for several pathologies that result in pigmentation defects in both mouse and humans.

Full Text - How Rab proteins link motors to membranes | PDF (261 KB) - How Rab proteins link motors to membranes

See also: Article by Wu et al.

Focus on signalling and adhesion

A double-edged sword - pE79

Valerie Ferrier

doi:10.1038/ncb0402-e79

Full Text - A double-edged sword | PDF (94 KB) - A double-edged sword

Focus on signalling and adhesion

In search of sticky protocols - pE80

Frans Van Roy reviews Cell–Cell Interactions by Tom Fleming & Spencer Muse

doi:10.1038/ncb0402-e80

Full Text - In search of sticky protocols | PDF (85 KB) - In search of sticky protocols

Signalling across the Internet - pE82

doi:10.1038/ncb0402-e82

Full Text - Signalling across the Internet | PDF (244 KB) - Signalling across the Internet

Focus on signalling and adhesion

Sensing the environment: a historical perspective on integrin signal transduction - ppE83 - E90

Cindy K. Miranti & Joan S. Brugge

doi:10.1038/ncb0402-e83

Abstract - | Full Text - Sensing the environment: a historical perspective on integrin signal transduction | PDF (737 KB) - Sensing the environment: a historical perspective on integrin signal transduction | Supplementary information

Focus on signalling and adhesion

Microscope-based techniques to study cell adhesion and migration - ppE91 - E96

Partha Roy, Zenon Rajfur, Pawel Pomorski & Ken Jacobson

doi:10.1038/ncb0402-e91

Abstract - | Full Text - Microscope-based techniques to study cell adhesion and migration | PDF (433 KB) - Microscope-based techniques to study cell adhesion and migration

Focus on signalling and adhesion

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again - ppE97 - E100

Donna J. Webb, J. Thomas Parsons & Alan F. Horwitz

doi:10.1038/ncb0402-e97

Abstract - | Full Text - Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again | PDF (167 KB) - Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

Focus on signalling and adhesion

Intercellular adhesion, signalling and the cytoskeleton - ppE101 - E108

Colin Jamora & Elaine Fuchs

doi:10.1038/ncb0402-e101

Abstract - | Full Text - Intercellular adhesion, signalling and the cytoskeleton | PDF (905 KB) - Intercellular adhesion, signalling and the cytoskeleton

Identification of an organelle receptor for myosin-Va - pp271 - 278

Xufeng S. Wu, Kang Rao, Hong Zhang, Fei Wang, James R. Sellers, Lydia E. Matesic, Neal G. Copeland, Nancy A. Jenkins & John A. Hammer, III

doi:10.1038/ncb760

Abstract - | Full Text - Identification of an organelle receptor for myosin-Va | PDF (1,384 KB) - Identification of an organelle receptor for myosin-Va

See also: News and Views by Goud

Quantal release of free radicals during exocytosis of phagosomes - pp279 - 285

Anke Di, Boris Krupa, Vytas P. Bindokas, Yimei Chen, Mary E. Brown, H. Clive Palfrey, Anjaparavanda P. Naren, Kevin L. Kirk & Deborah J. Nelson

doi:10.1038/ncb771

Abstract - | Full Text - Quantal release of free radicals during exocytosis of phagosomes | PDF (915 KB) - Quantal release of free radicals during exocytosis of phagosomes | Supplementary information

Focus on signalling and adhesion

Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins - pp286 - 293

Zenon Rajfur, Partha Roy, Carol Otey, Lewis Romer & Ken Jacobson

doi:10.1038/ncb772

Abstract - | Full Text - Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins | PDF (1,827 KB) - Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins | Supplementary information

Focus on signalling and adhesion

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton - pp294 - 301

Mira Krendel, Frank T. Zenke & Gary M. Bokoch

doi:10.1038/ncb773

Abstract - | Full Text - Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton | PDF (1,175 KB) - Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton | Supplementary information

See also: News and Views by Schuldt

Myosin IXb is a single-headed minus-end-directed processive motor - pp302 - 306

Akira Inoue, Junya Saito, Reiko Ikebe & Mitsuo Ikebe

doi:10.1038/ncb774

Abstract - | Full Text - Myosin IXb is a single-headed minus-end-directed processive motor | PDF (668 KB) - Myosin IXb is a single-headed minus-end-directed processive motor | Supplementary information

Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide - pp307 - 311

Ulrike Zabel, Christoph Kleinschnitz, Phil Oh, Pavel Nedvetsky, Albert Smolenski, Helmut Müller, Petra Kronich, Peter Kugler, Ulrich Walter, Jan E. Schnitzer & Harald H. H. W. Schmidt

doi:10.1038/ncb775

Abstract - | Full Text - Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide | PDF (292 KB) - Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide

The myosin converter domain modulates muscle performance - pp312 - 317

Douglas M. Swank, Aileen F. Knowles, Jennifer A. Suggs, Floyd Sarsoza, Annie Lee, David W. Maughan & Sanford I. Bernstein

doi:10.1038/ncb776

Abstract - | Full Text - The myosin converter domain modulates muscle performance | PDF (940 KB) - The myosin converter domain modulates muscle performance

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation - pp318 - 322

Niels Mailand, Claudia Lukas, Brett K. Kaiser, Peter K. Jackson, Jiri Bartek & Jiri Lukas

doi:10.1038/ncb777

Abstract - | Full Text - Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation | PDF (2,655 KB) - Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation | Supplementary information

Focus on signalling and adhesion

Identification of a link between the tumour suppressor APC and the kinesin superfamily - pp323 - 327

Takeshi Jimbo, Yoshihiro Kawasaki, Ryo Koyama, Rina Sato, Shinji Takada, Keiko Haraguchi & Tetsu Akiyama

doi:10.1038/ncb779

Abstract - | Full Text - Identification of a link between the tumour suppressor APC and the kinesin superfamily | PDF (2,734 KB) - Identification of a link between the tumour suppressor APC and the kinesin superfamily

erratum - p328

doi:10.1038/ncb765

Full Text - erratum | PDF (39 KB) - erratum

erratum - p328

doi:10.1038/ncb769

Full Text - erratum | PDF (39 KB) - erratum

Erratum: TGF- induces apoptosis through Smad-mediated expression of DAP-kinase - p328

doi:10.1038/ncb778

Full Text - Erratum: TGF- induces apoptosis through Smad-mediated expression of DAP-kinase | PDF (39 KB) - Erratum: TGF- induces apoptosis through Smad-mediated expression of DAP-kinase

erratum - p328

doi:10.1038/ncb780

Full Text - erratum | PDF (39 KB) - erratum