Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell–cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial–mesenchymal transitions under physiological and pathological conditions.
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Pece, S., Gutkind, J. E-cadherin and Hakai: signalling, remodeling or destruction?. Nat Cell Biol 4, E72–E74 (2002). https://doi.org/10.1038/ncb0402-e72
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DOI: https://doi.org/10.1038/ncb0402-e72
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