And the winner is . . . . - pE41

doi:10.1038/35055143

Recognition by one's peers is usually the only reward for a scientist. But recent popular awards show that the perception of scientists is changing.

Full Text - And the winner is . . . . | PDF (55 KB) - And the winner is . . . .

Death by design: the big debut of small molecules - ppE43 - E46

Timothy S. Zheng

doi:10.1038/35055145

Members of the Bcl-2 family are critical regulators of apoptosis and have become attractive targets for the development of anti-cancer drugs. The latest discovery of small-molecule inhibitors of Bcl-2 proteins may provide the sought-after leads for the development of new anti-cancer therapy

Full Text - Death by design: the big debut of small molecules | PDF (397 KB) - Death by design: the big debut of small molecules

Migration on the borderline - pE45

Sarah Greaves

doi:10.1038/35055149

Full Text - Migration on the borderline | PDF (52 KB) - Migration on the borderline

S-nitrosylation: spectrum and specificity - ppE46 - E49

Douglas T. Hess, Akio Matsumoto, Raphael Nudelman & Jonathan S. Stamler

doi:10.1038/35055152

Nitric oxide regulates a broad functional spectrum of proteins by S-nitrosylation. Specificity is conferred by acid–base and hydrophobic motifs that target critical cysteine residues and by protein–protein interactions that confine the signals in space.

Full Text - S-nitrosylation: spectrum and specificity | PDF (198 KB) - S-nitrosylation: spectrum and specificity

Wasting away - pE48

Anglela Eggleston

doi:10.1038/35055155

Full Text - Wasting away | PDF (118 KB) - Wasting away

Geminin bans replication licence - ppE49 - E50

Mark Madine & Ron Laskey

doi:10.1038/35055158

Recent work has clarified how higher eukaryotic cells 'licence' DNA replication precisely once per cycle. An inhibitor, geminin, prevents replication before mitosis by inhibiting the replication factor Cdt1. Degradation of geminin in anaphase allows Cdt1 to promote binding of MCM proteins, and hence DNA replication.

Full Text - Geminin bans replication licence | PDF (98 KB) - Geminin bans replication licence

Molecular chaperones and the art of recognizing a lost cause - ppE51 - E53

Amie J. McClellan & Judith Frydman

doi:10.1038/35055162

Molecular chaperones have long been heralded as machines for folding and salvaging proteins. However, not every attempt to fold or refold a protein can be successful. Chaperones are known to participate in the degradation of misfolded polypeptides, but a direct link between folding and degradation pathways has remained elusive. Two recent reports show that the co-chaperone CHIP mediates ubiquitin-dependent degradation of substrates bound to heat-shock protein 70 (Hsp70) and/or Hsp90.

Full Text - Molecular chaperones and the art of recognizing a lost cause | PDF (114 KB) - Molecular chaperones and the art of recognizing a lost cause

Chemokines: back to the future? - ppE53 - E54

Craig Gerard & Norma P. Gerard

doi:10.1038/35055166

Chemokines are generally appreciated within the realm of immunology as chemoattractant cytokines that are involved in constitutive and inducible movement of white blood cells. However, evidence increasingly points to a broader function of chemokines in cellular and developmental biology, and the initially T-associated chemokine RANTES has now been shown to produce age-dependent effects on developing human astrocytes.

Full Text - Chemokines: back to the future? | PDF (88 KB) - Chemokines: back to the future?

Xenotransplantation: overview of the key issues - pE55

Mauro S. Sandrin reviews XENO: the Promise of Transplanting Animal Organs into Humans by David K. C. Cooper & Robert P. Lanza

doi:10.1038/35055169

Full Text - Xenotransplantation: overview of the key issues | PDF (104 KB) - Xenotransplantation: overview of the key issues

Beyond the language of cell polarity - pE56

Cara Gottardi reviews Cell Polarity by

doi:10.1038/35055172

Full Text - Beyond the language of cell polarity | PDF (100 KB) - Beyond the language of cell polarity

Predicting the complicated - pE57

Paul Janmey reviews Chance in Biology by M. Denny & S. Gaines

doi:10.1038/35055175

Full Text - Predicting the complicated | PDF (109 KB) - Predicting the complicated

A profile of fertilization in mammals - ppE59 - E64

Paul M. Wassarman, Luca Jovine & Eveline S. Litscher

doi:10.1038/35055178

Abstract - | Full Text - A profile of fertilization in mammals | PDF (421 KB) - A profile of fertilization in mammals

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin - pp107 - 113

Shusuke Tada, Anatoliy Li, Domenico Maiorano, Marcel Méchali & J. Julian Blow

doi:10.1038/35055000

Abstract - | Full Text - Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin | PDF (549 KB) - Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases - pp114 - 120

Angela Taddei, Christèle Maison, Danièle Roche & Geneviève Almouzni

doi:10.1038/35055010

Abstract - | Full Text - Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases | PDF (3,255 KB) - Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases | Supplementary information

Lack of an endothelial store-operated Ca²⁺ current impairs agonist-dependent vasorelaxation in TRP4^-/- mice - pp121 - 127

Marc Freichel, Suk Hyo Suh, Alexander Pfeifer, Ulli Schweig, Claudia Trost, Petra Weigerber, Martin Biel, Stephan Philipp, Doris Freise, Guy Droogmans, Franz Hofmann, Veit Flockerzi & Bernd Nilius

doi:10.1038/35055019

Abstract - | Full Text - Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice | PDF (724 KB) - Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity - pp128 - 133

Peter Liston, Wai Gin Fong, N. Lynn Kelly, Shingo Toji, Toshiaki Miyazaki, Damiano Conte, Katsuyuki Tamai, Constance G. Craig, Michael W. McBurney & Robert G. Korneluk

doi:10.1038/35055027

Abstract - | Full Text - Identification of XAF1 as an antagonist of XIAP anti-Caspase activity | PDF (349 KB) - Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator - pp134 - 139

Tudorita Tumbar & Andrew S. Belmont

doi:10.1038/35055033

Abstract - | Full Text - Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator | PDF (1,021 KB) - Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator

Multicolour imaging of post-Golgi sorting and trafficking in live cells - pp140 - 149

Patrick Keller, Derek Toomre, Elena Díaz, Jamie White & Kai Simons

doi:10.1038/35055042

Abstract - | Full Text - Multicolour imaging of post-Golgi sorting and trafficking in live cells | PDF (1,714 KB) - Multicolour imaging of post-Golgi sorting and trafficking in live cells

RANTES promotes growth and survival of human first-trimester forebrain astrocytes - pp150 - 157

Moiz Bakhiet, Annelie Tjernlund, Alyaa Mousa, Annica Gad, Staffan Strömblad, William A. Kuziel, Åke Seiger & Jan Andersson

doi:10.1038/35055057

Abstract - | Full Text - RANTES promotes growth and survival of human first-trimester forebrain astrocytes | PDF (1,141 KB) - RANTES promotes growth and survival of human first-trimester forebrain astrocytes

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress - pp158 - 164

Takao Iwawaki, Akira Hosoda, Tetsuo Okuda, Yusuke Kamigori, Chizumi Nomura-Furuwatari, Yukio Kimata, Akio Tsuru & Kenji Kohno

doi:10.1038/35055065

Abstract - | Full Text - Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress | PDF (1,593 KB) - Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress | Supplementary information

Growth-factor-dependent mitogenesis requires two distinct phases of signalling - pp165 - 172

Steven M. Jones & Andrius Kazlauskas

doi:10.1038/35055073

Abstract - | Full Text - Growth-factor-dependent mitogenesis requires two distinct phases of signalling | PDF (456 KB) - Growth-factor-dependent mitogenesis requires two distinct phases of signalling | Supplementary information

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-x_L - pp173 - 182

Alexei Degterev, Alexey Lugovskoy, Michael Cardone, Bradley Mulley, Gerhard Wagner, Timothy Mitchison & Junying Yuan

doi:10.1038/35055085

Abstract - | Full Text - Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL | PDF (817 KB) - Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3 - pp183 - 191

Shie-Pon Tzung, Kristine M. Kim, Gorka Basañez, Chris D. Giedt, Julian Simon, Joshua Zimmerberg, Kam Y. J. Zhang & David M. Hockenbery

doi:10.1038/35055095

Abstract - | Full Text - Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3 | PDF (708 KB) - Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide - pp193 - 197

Samie R. Jaffrey, Hediye Erdjument-Bromage, Christopher D. Ferris, Paul Tempst & Solomon H. Snyder

doi:10.1038/35055104

Abstract - | Full Text - Protein S-nitrosylation: a physiological signal for neuronal nitric oxide | PDF (303 KB) - Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

Escape from premature senescence is not sufficient for oncogenic transformation by Ras - pp198 - 203

Daniel S. Peeper, Jan-Hermen Dannenberg, Sirith Douma, Hein te Riele & René Bernards

doi:10.1038/35055110

Abstract - | Full Text - Escape from premature senescence is not sufficient for oncogenic transformation by Ras | PDF (483 KB) - Escape from premature senescence is not sufficient for oncogenic transformation by Ras | Supplementary information

Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis - pp204 - 209

Jiong Chen, Dorothea Godt, Kris Gunsalus, Istvan Kiss, Michael Goldberg & Frank A. Laski

doi:10.1038/35055120

Abstract - | Full Text - Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis | PDF (383 KB) - Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis | Supplementary information

Origin of eukaryotic cell nuclei by symbiosis of Archaea in Bacteria is revealed by homology-hit analysis - pp210 - 214

Tokumasa Horiike, Kazuo Hamada, Shigehiko Kanaya & Takao Shinozawa

doi:10.1038/35055129

Abstract - | Full Text - Origin of eukaryotic cell nuclei by symbiosis of Archaea in Bacteria is revealed by homology-hit analysis | PDF (214 KB) - Origin of eukaryotic cell nuclei by symbiosis of Archaea in Bacteria is revealed by homology-hit analysis

Caenorhabditis elegans auxilin: a J-domain protein essential for clathrin-mediated endocytosis in vivo - pp215 - 219

Tsvika Greener, Barth Grant, Yinhua Zhang, Xufeng Wu, Lois E. Greene, David Hirsh & Evan Eisenberg

doi:10.1038/35055137

Abstract - | Full Text - Caenorhabditis elegans auxilin: a J-domain protein essential for clathrin-mediated endocytosis in vivo | PDF (1,891 KB) - Caenorhabditis elegans auxilin: a J-domain protein essential for clathrin-mediated endocytosis in vivo