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Reducing interferon'ce in stem cells

Nature Cell Biology volume 19, pages 597–599 (2017)Cite this article

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Little is known regarding how the interactions of stem cells with the immune system regulate their plasticity. A study now describes a mechanism by which normal breast and cancer stem cells utilize miR-199a to downregulate the corepressor LCOR and minimize responses to type I interferon.

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Figure 1: Regulation of stemness by controlling cellular responses to type I IFNs through the miR-199a–LCOR axis.

References

  1. Visvader, J. E. & Clevers, H. Nat. Cell Biol. 18, 349–355 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Visvader, J. E. & Stingl, J. Genes Dev. 28, 1143–1158 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Shenoy, A. & Blelloch, R. H. Nat. Rev. Mol. Cell Biol. 15, 565–576 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Gangaraju, V. K. & Lin, H. Nat. Rev. Mol. Cell Biol. 10, 116–125 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Aurora, A. B. & Olson, E. N. Cell Stem Cell 15, 14–25 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Celià-Terrassa, T. et al. Nat. Cell Biol. 19, 711–723 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  7. O'Brien, J. et al. Am. J. Pathol. 176, 1241–1255 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Cheng, W., Liu, T., Wan, X., Gao, Y. & Wang, H. FEBS J. 279, 2047–2059 (2012).

    Article  CAS  PubMed  Google Scholar 

  9. Liu, R. et al. Oncotarget 7, 56628–56642 (2016).

    PubMed  PubMed Central  Google Scholar 

  10. Hu, Y. et al. Dig. Dis. Sci. 59, 2163–2172 (2014).

    Article  CAS  PubMed  Google Scholar 

  11. Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J. & Kroemer, G. Nat. Rev. Immunol. 15, 405–414 (2015).

    Article  CAS  PubMed  Google Scholar 

  12. Chen, H. M. et al. Cancer Sci. 100, 449–456 (2009).

    Article  CAS  PubMed  Google Scholar 

  13. Maccalli, C., Volontè, A., Cimminiello, C. & Parmiani, G. Eur. J. Cancer 50, 649–655 (2014).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, 33612, Florida, USA

    Alycia Gardner & Brian Ruffell

  2. Cancer Biology PhD Program, University of South Florida, Tampa, 33620, Florida, USA

    Alycia Gardner

  3. Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, 33612, Florida, USA

    Brian Ruffell

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  1. Alycia Gardner
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  2. Brian Ruffell
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Correspondence to Brian Ruffell.

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The authors declare no competing financial interests.

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Gardner, A., Ruffell, B. Reducing interferon'ce in stem cells. Nat Cell Biol 19, 597–599 (2017). https://doi.org/10.1038/ncb3544

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